Transversus Abdominis Plane Block Versus Wound Infiltration for Pulmonary Function Preservation Following Laparoscopic Living Donor Nephrectomy (The TAPWIN Trial): A Double-Blind Randomized Controlled Trial

Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This study compares two pain control techniques in patients undergoing laparoscopic kidney donation surgery: transversus abdominis plane (TAP) block versus wound infiltration with local anesthetic. Postoperative pain can impair breathing by causing patients to take shallow breaths to avoid discomfort. This study will evaluate which technique better preserves lung function, specifically peak expiratory flow (PEF), after surgery. Eighty patients will be randomly assigned to receive either a TAP block (injection of local anesthetic into the abdominal wall muscles before surgery) or wound infiltration (injection of local anesthetic at the incision sites at the end of surgery). Both patients and the staff measuring outcomes will be blinded to group assignment. The primary outcome is the percentage change in PEF from before surgery to discharge from the recovery room. Secondary outcomes include pain scores, opioid use, breathing complications, and length of hospital stay.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Patients who are scheduled to undergo elective LLDN.

• Age above 18 years.

• Body Mass Index (BMI) above 20 and below 40 kg m-2.

• Eligible to sign informed consent.

Locations
Other Locations
Israel
Rabin Medical Center, Beilinson Hospital
RECRUITING
Petah Tikva
Contact Information
Primary
Karam Azem, MD
dr.azem.k@gmail.com
+972 50 470 5001
Time Frame
Start Date: 2026-01-01
Estimated Completion Date: 2027-02-01
Participants
Target number of participants: 80
Treatments
Experimental: TAP Block Group
After anesthesia induction and before surgical incision, the anesthesiologist will perform an ultrasound-guided (Venue GO, GE Healthcare, USA) single-shot TAP block in the triangle of Petit with 20 mL 0.25% bupivacaine and 2.5 µg mL-1 of epinephrine on each side.
Active_comparator: Wound Infiltration Group
Following surgery conclusion and before awakening from anesthesia, the surgeons will inject 40 mL of 0.25% bupivacaine and 2.5 µg mL-1 of epinephrine at the wound sites.
Related Therapeutic Areas
Sponsors
Leads: Rabin Medical Center

This content was sourced from clinicaltrials.gov

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