Efficacy of Ropivacaine Epinephrine Clonidine Ketorolac (R.E.C.K) vs Exparel in Robotic Nephrectomy: a Randomized, Prospective Trial

Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 3
SUMMARY

The purpose of the study is to evaluate the efficacy of R.E.C.K (ropivacaine epinephrine clonidine ketorolac) vs Exparel during robotic partial and radical nephrectomy in a single institution, prospective, randomized trial. The study will evaluate post operative Numerical Rating Score (NRS) pain scores, post operative pain medication intake (opioids and over-the-counter pain medicines) and length of stay across the two patient cohorts. The findings will help to inform whether the increased cost of Exparel when compared to R.E.C.K is justified.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Ability to understand and willingness to sign an IRB-approved informed consent

• Age ≥ 18 years at the time of consent.

• Planned robotic partial or radical nephrectomy

Locations
United States
North Carolina
Levine Cancer
RECRUITING
Charlotte
Time Frame
Start Date: 2025-11-14
Estimated Completion Date: 2027-10
Participants
Target number of participants: 170
Treatments
Active_comparator: Arm A
Intraoperative R.E.C.K.
Experimental: Arm B
Intraoperative Exparel
Related Therapeutic Areas
Sponsors
Collaborators: Atrium Health Levine Cancer Institute
Leads: Wake Forest University Health Sciences

This content was sourced from clinicaltrials.gov