Novel Biomarkers to Predict Acute Kidney Injury and Chronic Kidney Disease After Radical Nephrectomy: an Exploratory Prospective Cohort Study
Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY
The incidence of acute kidney injury (AKI) after radical nephrectomy exceeds 40%. Currently, the KDIGO criteria are the recognized diagnostic standard for AKI. These criteria primarily use serum creatinine and urine output as key indicators, but both parameters have certain limitations, such as delayed response, insensitivity, and inaccuracy. This study aims to simultaneously monitor perioperative novel renal damaging, stressful, and functional biomarkers in patients undergoing radical nephrectomy, and to investigate their predictive value for AKI and postoperative 1-year chronic kidney disease (CKD).
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Age ≥18 years;
• Scheduled to undergo unilateral radical nephrectomy.
Locations
Other Locations
China
Department of Anesthesiology and Critical Care Medicine, Peking University First Hospital
RECRUITING
Beijing
Contact Information
Primary
Qiongfang Wu, MD
wuqf91@163.com
8610 83572460
Time Frame
Start Date: 2025-08-02
Estimated Completion Date: 2027-07-30
Participants
Target number of participants: 60
Treatments
AKI group/CKD group
1. patients diagnosed with AKI after radical nephrectomy.~2. patients diagnosed with the new onset/worsening of CKD after radical nephrectomy.
non-AKI group/non-CKD group
1. patients without AKI after radical nephrectomy.~2. patients without new onset/worsening of CKD after radical nephrectomy.
Related Therapeutic Areas
Sponsors
Leads: Peking University First Hospital