Lidocaine Versus Bupivacaine in Orthognathic Surgery: A Randomized Controlled Trial
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 4
SUMMARY
In this research study, we want to learn more about the impact of two different local anesthetics (bupivacaine and lidocaine) on patient experience following orthognathic (jaw) surgery. Both anesthetics are within the standard of care for dental and orthognathic procedures, but can vary in how quickly they take action and how long they last. This study will provide us with a greater understanding of how anesthetic choice affect patient outcomes, and how we can strive to make these outcomes as favorable as possible.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 15
Maximum Age: 35
Healthy Volunteers: t
View:
• Undergoing an orthognathic procedure at Boston Children's Hospital
• Between the ages of 15 and 35 years old
Locations
United States
Massachusetts
Boston Children's Hospital
RECRUITING
Boston
Contact Information
Primary
Michael C Britt
michael.britt@childrens.harvard.edu
6179192279
Backup
Katie Bridges
katie.bridges@childrens.harvard.edu
6179191495
Time Frame
Start Date: 2024-07-26
Estimated Completion Date: 2026-07-01
Participants
Target number of participants: 100
Treatments
Active_comparator: Bupivacaine Left, Lidocaine Right
Group 1 will receive 10 cc of 0.25% bupivacaine hydrochloride with 1:200,000 epinephrine on the left side of their jaw and 6.8 cc of 2% lidocaine hydrochloride with 1:100,000 epinephrine on the right side of their jaw. This dosage will be administered once as peripheral nerve blocks at the beginning of the participant's orthognathic procedure.
Active_comparator: Bupivacaine Right, Lidocaine Left
Group 2 will receive 10 cc of 0.25% bupivacaine hydrochloride with 1:200,000 epinephrine on the right side of their jaw and 6.8 cc of 2% lidocaine hydrochloride with 1:100,000 epinephrine on the left side of their jaw. This dosage will be administered once as peripheral nerve blocks at the beginning of the participant's orthognathic procedure.
Related Therapeutic Areas
Sponsors
Leads: Boston Children's Hospital