18F-choline-PET-CT vs Ultrasonography and 99-technetium Sestamibi Scintigraphy in Preoperative Localization for pHPT - A Randomized Trial

Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of this open, single-center, prospective, randomized, clinical study is to compare imaging with \[18F\]fluoromethyl-dimethyl-2-hydroxyethylammonium (18F-choline) positron-emission-tomography - computed-tomography, 18F-ch-PETCT, to conventional imaging with ultrasonography and sestamibi scintigraphy in localizing diseased parathyroid glands in patients diagnosed with primary hyperparathyroidism, pHPT. The question this study aims to answer is: can 18-F-ch-PET-CT more precisely localize diseased parathyroid glands in patients with pHPT before surgery? The objective of the study is to help improve precision in parathyroid surgery, thereby increasing cure rates, minimizing complications, and shortening operation times.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Proven primary hyperparathyroidism Indication for surgery Adult (\>18 years)

Locations
Other Locations
Sweden
Skåne University Hospital
RECRUITING
Lund
Contact Information
Primary
Martin Almquist
martin.almquist@med.lu.se
+46-46176245
Time Frame
Start Date: 2023-01-01
Estimated Completion Date: 2027-02-28
Participants
Target number of participants: 88
Treatments
Experimental: 18-F-choline-PET
Investigation with 18-F-choline-PET-CT
Active_comparator: Conventional
Conventional (standard) imaging with ultrasonography and sestamibi scintigraphy
Related Therapeutic Areas
Sponsors
Leads: Region Skane

This content was sourced from clinicaltrials.gov