Multivessel Balloon Occlusion to Investigate Obstructive Coronary Artery Disease and aNgina
ORBITA-MOON is a double-blinded, placebo-controlled experimental study that aims to understand how the different coronary artery stenoses contribute to overall clinical angina in patients with multi-vessel coronary artery disease. This study will investigate the symptoms conferred by each stenosis, induced by experimental ischaemia, for 60 patients with multi-vessel coronary artery disease.
• Eligibility for PCI due to angina
• Anatomical evidence of significant multi-vessel coronary stenosis defined by either:
∙ ≥70% stenosis in two or more coronary arteries of ≥2.5mm visual diameter stenosis, on invasive coronary angiography (ICA)
‣ Severe stenosis in ≥2 coronary arteries of ≥ 2.5mm visual diameter stenosis, on CTCA
• Physiological evidence of ischaemia with a positive test corresponding to the coronary arteries to be stented, on at least one of the following:
‣ dobutamine stress echocardiogram
⁃ cardiac MRI
⁃ myocardial perfusion study
⁃ invasive metrics of coronary physiology