Prospective Study of siMultaneous Adaptive RadioTherapy for Local Boost for Prostate and Bladder Cancers (SMART-B01)

Status: Recruiting
Location: See location...
Intervention Type: Radiation
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of this clinical trial is to learn if adaptive radiation boost works to treat genitourinary cancers, esp. in the context of prostate cancer patients with post-prostatectomy local relapse and bladder cancer patients with bladder-conserving treatment. It will also learn about the safety and efficacy of adaptive boost. The main questions it aims to answer are: Does adaptive boost lower the toxicities? Does adaptive boost maintain or improve the clinical efficacy? Participants will: Undergo adaptive boost on 1.5-Tesla MR-Linac Visit the clinic once every 2 weeks during RT, and every 3 months post-ART Keep a regular QOL questinnaire completion

Eligibility
Participation Requirements
Sex: Male
Minimum Age: 18
Healthy Volunteers: f
View:

• Patients with newly diagnosed or metastatic/recurrent pathologically confirmed urological tumors, clinically assessed as suitable for adaptive radiotherapy;

• Age ≥ 18 years;

• ECOG performance status score 0-2;

• No prior radiotherapy history within the current radiation field;

• No contraindications for MRI scanning;

• No contraindications for radiotherapy.

Locations
Other Locations
China
Cancer Hospital, National Cancer Center, CAMS & PUMC
RECRUITING
Beijing
Contact Information
Primary
Ning-Ning Lu, M.D.
ningninglu09@163.com
861018611804268
Time Frame
Start Date: 2024-12-01
Estimated Completion Date: 2028-12-31
Participants
Target number of participants: 60
Treatments
Experimental: Experimental arm
Pts will receive adaptive boost for clinically significant disease
Sponsors
Leads: Cancer Institute and Hospital, Chinese Academy of Medical Sciences

This content was sourced from clinicaltrials.gov

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