The Use of Dexamethasone in Total Thyroidectomy to Improve Voice Outcome and Hypocalcaemia

Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 2
SUMMARY

Thyroidectomy is a standard procedure for benign and malignant pathologies of the thyroid gland. Each year, some 100 total thyroidectomies are performed in Kowloon East Cluster, Hospital Authority, Hong Kong. Total thyroidectomy is associated with voice dysfunction and temporary hypocalcaemia in up to 80% and 50%, respectively. Previous study from our institute showed a 3% rate of permanent vocal cord palsy and 16% of permanent hypoparathyroidism requiring calcium and/or vitamin D supplements. The use of dexamethasone has been studied in the past in total thyroidectomy patients and has been shown to be safe and effective in improving post-operative nausea and vomiting. No complications or drug related side effects were associated with a single dose of steroid. Recent studies have also shown that Dexamethasone is effective in improving voice outcome and hypocalcaemia in thyroidectomy patients. The investigators aim to study the effect of Dexamethasone in post-operative voice outcome and hypocalcaemia. Objective assessment of the vocal cords during phonation will be performed pre-operative and post-operatively. Serum Calcium level will be monitored.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: t
View:

• Aged 18 or above

• Patients undergoing total thyroidectomy for benign pathologies

• MNG

• Toxic nodular goitre

• Graves' disease

Locations
Other Locations
Hong Kong Special Administrative Region
Department of Otorhinolaryngology, Head and Neck Surgery, United Christian Hospital and Tseung Kwan O Hospital
RECRUITING
Hong Kong
Contact Information
Primary
Cherrie Ng
cherrieng@ent.cuhk.edu.hk
+85235051409
Backup
Thomas Hui, BSc
hsc526@ha.org.hk
+85239493549
Time Frame
Start Date: 2024-07-01
Estimated Completion Date: 2026-09-30
Participants
Target number of participants: 100
Treatments
Experimental: Dexamethasone group
One dose of 8mg in 2ml Dexamethasone will be given
Placebo_comparator: Placebo group
One dose of 2ml 0.9% Normal saline will be given
Related Therapeutic Areas
Sponsors
Collaborators: Chinese University of Hong Kong, United Christian Hospital
Leads: Tseung Kwan O Hospital, Hong Kong

This content was sourced from clinicaltrials.gov