Muscle Connective Tissue in Limb Development and Disease
Status: Recruiting
Location: See all (5) locations...
Intervention Type: Procedure
Study Type: Observational
SUMMARY
The objective of this work is to understand how the disruption of the muscle connective tissue contributes to the limb soft-tissue defects in radial dysplasia. In parallel, the researchers will investigate the role of muscle connective tissue in normal limb development.
Eligibility
Participation Requirements
Sex: All
Healthy Volunteers: f
View:
• Patients with a clinical diagnosis of radial dysplasia, requiring reconstructive surgery
• Either sex
• Informed (parental) consent to participate
• Patients with an injury requiring reconstructive surgery
• Either sex
• Informed (parental) consent to participate
Locations
Other Locations
United Kingdom
Chelsea and Westminster Hospital NHS Foundation Trust
RECRUITING
London
Great Ormond Street Hospital for Children NHS Foundation Trust
RECRUITING
London
Guy's and St Thomas' Hospital
RECRUITING
London
Royal Free Hospital
RECRUITING
London
Oxford University Hospitals
RECRUITING
Oxford
Contact Information
Primary
Malcolm Logan, BSc PhD
malcolm.logan@kcl.ac.uk
02078486886
Backup
George Murphy, PhD FRCS
george.murphy@gosh.nhs.uk
Time Frame
Start Date: 2016-02-20
Estimated Completion Date: 2036-08
Participants
Target number of participants: 150
Treatments
Radial dysplasia patients
Recruited participants will have 2-3 small tissue biopsy samples taken during 1-2 of their planned reconstructive surgical procedures for radial dysplasia, whilst under general anaesthesia in the operating theatre. Samples will be taken by scalpel or scissors, by the operating surgeon, from within the surgical site in the forearm and hand. The skin incision and deep dissection will have to be made as part of the normal course of reconstructive surgery, regardless of participation in this study.
Control patients
Recruited participants will have 2-3 small tissue biopsy samples taken during their planned reconstructive surgery for hand trauma, whilst under general anaesthesia in the operating theatre. Samples will be taken by scalpel or scissors, by the operating surgeon, from within the surgical site in the forearm and hand. The skin incision and deep dissection will have to be made as part of the normal course of reconstructive surgery, regardless of participation in this study.
Authors
Bran Sivakumar, Lucy Cogswell
Related Therapeutic Areas
Sponsors
Collaborators: Chelsea and Westminster NHS Foundation Trust, Great Ormond Street Hospital for Children NHS Foundation Trust, Royal Free Hospital NHS Foundation Trust
Leads: King's College London