Dynamic Parameters of Glucose Control in Relation to Biomarkers in Serum and Intraocular Fluid in Diabetic Patients With Ocular Complications
Status: Recruiting
Intervention Type: Procedure
Study Type: Observational
SUMMARY
Our project investigates the new characteristics of diabetic retinopathy using liquid eye biopsy in combination with novel parameters of glucose control obtained with continuous glucose monitoring. This approach will bring new knowledge and implications for future therapies.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• type 1 or type 2 diabetes
• ≥ 18 years old
• treatment with insulin for at least 5 years prior baseline
• any form of diabetic retinopathy and macular edema
• HbA1c \< 10%
• written informed consent prior to starting study related activity
Contact Information
Primary
Martin Prázný, Prof.
mpra@lf1.cuni.cz
+420737122570
Backup
Petra Svozílková, Prof.
petra.svozilkova@lf1.cuni.cz
+420604801153
Time Frame
Start Date: 2022-04-01
Estimated Completion Date: 2026-06-01
Participants
Target number of participants: 213
Treatments
Patients with DR
Adult patients with T1DM or T2DM with any form of diabetic retinopathy and diabetic macular edema, indicated for ocular surgical procedure as standard of care. Blood samples and samples of intraocular fluids will bee taken during the ocular surgery.
Patients without DR
Adult patients with T1DM or T2DM without any signs of diabetic retinopathy, indicated for ocular surgical procedure from other reasons as standard of care. Blood samples and samples of intraocular fluids will bee taken during the ocular surgery.
Control group
Subjects without diabetes mellitus indicated for ocular surgery from other reasons (cataract, retinal detachment, macular hole, idiopathic epiretinal membrane) as standard of care. Blood samples and samples of intraocular fluids will bee taken during the ocular surgery.
Related Therapeutic Areas
Sponsors
Collaborators: Czech Health Research Council
Leads: Charles University, Czech Republic