Transcatheter Geniculate Arterial Embolization: Treatment and Monitoring of Response

Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test, Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The objective of this study is to investigate if MRI can be used to evaluated effect of knee artery embolization for knee osteoarthritis. Participants be evaluated in clinic, obtain a knee MRI, undergo embolization of the symptomatic knee, and follow up in clinic at 1, 6, and 12 months after embolization. A second MRI is obtained 6 months after embolization. Participants will keep a record of their pain level and treatment and answer questionnaires at each visit. In addition, this study aims to determine the effects of knee artery embolization on the amount of opioid (pain reliever drugs) needed to manage osteoarthritis-associated pain and change in quality of life.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 25
Maximum Age: 90
Healthy Volunteers: f
View:

• Age 25 to 90

• Symptomatic osteoarthritis of one or both knees, with Kellgren-Lawrence grade 1-3 assessed by weight-bearing knee radiography, including post-traumatic osteoarthritis

• One or more months of non-surgical therapy for knee pain such as joint injections, oral NSAIDs, or opioid analgesia

• Subjects able to provide informed consent. As this is a study of pain, patients must be able to consent for themselves.

• Patients without contraindication to MRI imaging with gadolinium-based contrast.

Locations
United States
South Carolina
Medical University of South Carolina
RECRUITING
Charleston
Contact Information
Primary
Samuel Bidwell
bidwells@musc.edu
843-792-2305
Time Frame
Start Date: 2022-10-01
Estimated Completion Date: 2026-06
Participants
Target number of participants: 12
Treatments
Experimental: GAE and MRI treatment arm
GAE is geniculate artery embolization.
Related Therapeutic Areas
Sponsors
Leads: Medical University of South Carolina
Collaborators: Bayer

This content was sourced from clinicaltrials.gov