Optimal Anesthetic for Corticosteroid Injections for Knee Osteoarthritis.
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 1
SUMMARY
To evaluate pain relief from corticosteroid injection with and without anesthetic as well as with variable volume of anesthetic. Pain relief will be measured using the VAS pain score at the time of the injection as well as several time points following the injection to capture pain relief longevity. The investigators intend to evaluate how well the patients tolerate corticosteroid mixtures without anesthetic as well as with different volumes of anesthetic. Primary measure will be the time from procedure when postoperative status is considered success (as measured by global perceived improvement score).
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: t
View:
• Patients must be 18 years of age and be able to consent for themselves.
• OA grade Kellgren Lawrence Stage II or III.
• Diagnosis of primary osteoarthritis.
Locations
United States
Florida
Florida Orthopaedic Institute
RECRUITING
Tampa
Contact Information
Primary
Anne Meredith Baldy, CCRC
ambaldy@foreonline.org
(813)978-9700
Backup
Debbi Warren, RN
dwarren@foreonline.org
(813)978-9700
Time Frame
Start Date:2023-06-01
Estimated Completion Date:2025-12-01
Participants
Target number of participants:75
Treatments
Experimental: Kenalog with 0ml bupivacaine
The intervention in this study is one intra-articular knee injection of synthetic corticosteroid (kenalog) and variable amount of anesthetic,0ml of bupivacaine. The patients will be randomized into this group.
Experimental: Kenalog with 4ml bupivacaine
The intervention in this study is one intra-articular knee injection of synthetic corticosteroid (kenalog) and variable amount of anesthetic,4ml of bupivacaine. The patients will be randomized into this group.
Experimental: Kenalog with 0.25% bupivacaine
The intervention in this study is one intra-articular knee injection of synthetic corticosteroid (kenalog) and variable amount of anesthetic,0.25% of bupivacaine. The patients will be randomized into this group.