Investigation of the Clinical Efficacy of Low-dose Ionizing Radiation in the Treatment of Osteoarthritis
IMMO-LDRT02 is a prospective, placebo-controlled, double-blind, randomized trial to investigate the clinical efficacy of low dose radiation therapy (LDRT) in the treatment of arthrosis. Newly diagnosed or already existing arthroses of the fingers, wrists, shoulders, knees, ankles and feet will be enclosed. Finally, the evidence of clinical benefit from LDRT (6 x 0.5 Gy) will be compared to the placebo group (6 x 0 Gy), by determination via a visual analog scale and identification of immunological changes.
• Diagnosed osteoarthritis according to ACR criteria (exclusion of other other arthritides and chronic rheumatoid arthritis via laboratory tests):
‣ Finger and wrist osteoarthritis
⁃ Elbow arthrosis
⁃ Shoulder arthrosis
⁃ Knee arthrosis
⁃ Ankle and foot joint arthrosis
• First time application of low-dose radiotherapy (LDRT) of the affected joint.
• Willingness to cooperate and accessibility of the patients (geographical proximity) for treatment and Follow-up care