The Efficacy of Hyaluronic Acid Injection as an Adjunctive Treatment After Intraarticular Low-dose Glucocorticoid Injection for Symptomatic Knee Osteoarthritis: A Multicenter Randomized, Controlled, Double-blinded Study

Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 4
SUMMARY

The aim of this clinical trial study is to compare the efficacy of Hyaluronic injection in patients with symptomatic knee osteoarthritis. The main questions it aims to answer are: * Is Hyaluronic acid injection improve pain symptom, joint stiffness, and joint function in patients with knee osteoarthritis * Is Hyaluronic acid injection improve knee performance status and health-related quality of life in patients with knee osteoarthritis Participants will be allocated to receive one treatments; either Hyaluronic acid or normal saline injections after receiving glucocorticoid injection. Researchers will compare the Hyaluronic acid with normal saline injection to see if the former show superior effect in terms of pain, joint stiffness, function, as well as health-related quality of life comparing with placebo.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 50
Healthy Volunteers: f
View:

• All participants who had been diagnosed as knee osteoarthritis according to ACR criteria with symptom of knee pain

• Pain visual analog scare of 4 or higher

Locations
Other Locations
Thailand
Phramongkutklao Hospital
RECRUITING
Bangkok
Contact Information
Primary
Nis Okuma, Medical
nitzumo@gmail.com
669-24759900
Time Frame
Start Date: 2024-02-10
Estimated Completion Date: 2025-06-30
Participants
Target number of participants: 176
Treatments
Active_comparator: Hyaluronic acid
Hyaluronic acid, Ostenil Plus, 2 mL (40 mg) will be injected once afer 2-4 week of glucocorticoid injection
Placebo_comparator: Normal saline
Two-millilitres of normal saline will be injected once after 2-4 weeks of glucocorticoid injection
Related Therapeutic Areas
Sponsors
Collaborators: Khon Kaen University, Chulalongkorn University, Police General Hospital
Leads: Phramongkutklao College of Medicine and Hospital

This content was sourced from clinicaltrials.gov