Fibrine Clot-augmented Repair of Longitudinal Meniscus Tears - A Prospectively Randomized Controlled Trial

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Longitudinal meniscal tears are a type of meniscal injury characterized by a displaced fragment of the meniscus that flips over into the joint, often resembling a buckle or handle. These tears typically occur in the medial meniscus and are often associated with traumatic knee injuries, particularly in athletes. The displaced meniscal fragment can cause mechanical symptoms such as locking, clicking, or catching of the knee, as well as pain and swelling. If not properly treated, buckle-handle meniscal tears can lead to further complications, including chronic knee instability, increased risk of osteoarthritis, and persistent joint pain.Repairing a longitudinal meniscal tear offers several advantages over partial meniscectomy, particularly in preserving knee function and preventing long-term complications. Meniscal repair aims to restore the integrity of the meniscus, which plays a crucial role in load distribution, shock absorption, and joint stability. Utilizing a fibrin clot during the repair of a buckle-handle meniscal tear can enhance the healing process and improve surgical outcomes. Fibrin clots act as a biological scaffold, promoting tissue regeneration by providing a matrix that facilitates cellular migration and proliferation. The purpose of this study was to compare longitudinal meniscal tear repair reinforced with fibrin clot with routine end-to-end repair in a prospective randomized controlled trial.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 50
Healthy Volunteers: f
View:

• Presenting with a painful meniscus (lateral or medial) longitudinal tear

• Being between the ages of 18 and 50

• Not having undergone surgery on the same knee before

• Having an MRI taken at the end of the 1st year post-surgery

Locations
Other Locations
Turkey
Ankara Bilkent City Hospital
RECRUITING
Ankara
Ankara Etlik City Hospital
RECRUITING
Ankara
Contact Information
Primary
Enejd Veizi, MD
dr.nad89@hotmail.com
+905439799959
Backup
Yasin Erdoğan, MD
yasin-erdgn@hotmail.com
+905056056097
Time Frame
Start Date: 2024-07-25
Estimated Completion Date: 2029-07-31
Participants
Target number of participants: 120
Treatments
Experimental: Fibrin Clot-augmented group
Patients in the experimental repair group will undergo routine meniscus repair surgery in addition to a fibrin clot placed within the ruptured sides using arthroscopic all-inside or inside-out sutures. The fibrin clot will be prepared from 50cc of bone marrow aspirate obtained from the iliac crest and mixed for 15 minutes. The clot will be shaped into a cylindrical form and compressed between the torn edges of the meniscus using a trocar system, then secured with sutures.
Active_comparator: Conventionally repaired group
Patients in the control repair group will undergo routine meniscus repair surgery using arthroscopic all-inside or inside-out sutures. The ruptured sides will be approximated as usual and the procedure will be considered completed.
Related Therapeutic Areas
Sponsors
Leads: Ankara City Hospital Bilkent
Collaborators: Ankara Etlik City Hospital

This content was sourced from clinicaltrials.gov