Investigating the Biomechanical and Functional Outcomes of Autologous Chondrocyte Implantation: A Multi-centre Study

Status: Recruiting
Location: See all (7) locations...
Intervention Type: Procedure
Study Type: Observational
SUMMARY

Injury to the knee can damage the lining of the knee's bones, called cartilage. Cartilage injuries cause pain and limit movement, making activities like walking, playing sports, and working difficult. Cartilage cannot repair itself well, so surgery is often needed to repair it. People who have cartilage repair surgery want to return to normal activities after their operation. Doctors and scientists know the operation can reduce pain, but do not fully understand how it affects movement. This research will help us see if knee function gets better after cartilage repair surgery. The results will help doctors and patients understand what to expect from the surgery. It could also uncover common problems after surgery that could be fixed with physiotherapy. This research is important because untreated cartilage injuries can develop into arthritis later in life. Arthritis is a painful lifelong condition that could be prevented by effectively treating the cartilage injury. In this study, adult patients who are waiting to have a type of cartilage repair surgery called 'autologous chondrocyte implantation' (ACI) at one of 7 hospitals will be invited to take part in the study by their surgeon. Patients who decide to take part will be invited to two appointments at their own hospital, where assessments of their knee function will be performed. The tests will assess the knee's movement, and the patient's balance and walking abilities. The first research appointment will take place before the operation, and the second and final appointment will take place 6-months after surgery. The results of this study will help us understand how knee function changes after cartilage repair surgery. The study will take place across 7 ACI centres in England, and is funded by Orthopaedic Research UK and the British Association for Surgery of the Knee.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Diagnosis of a chondral injury to the knee by a consultant orthopaedic surgeon Participants must have this diagnosis, else they are not eligible for ACI surgery.

• Listed for ACI for a chondral injury by a consultant orthopaedic surgeon Participants must be listed for ACI, as this is the treatment of interest in this research study

• Over 18 years old Participants must be legally capable of providing informed consent for the study.

Locations
Other Locations
United Kingdom
Royal Orthopaedic Hospital
NOT_YET_RECRUITING
Birmingham
Addenbrooke's Hospital
NOT_YET_RECRUITING
Cambridge
Chapel Allerton Orthopaedic Centre
RECRUITING
Leeds
Trafford General Hospital
RECRUITING
Manchester
Southampton General Hospital
NOT_YET_RECRUITING
Southampton
Royal National Orthopaedic Hospital
RECRUITING
Stanmore
New Cross Hospital
RECRUITING
Wolverhampton
Contact Information
Primary
Gwenllian F Tawy, PhD
gwenllian.tawy@manchester.ac.uk
01617462371
Time Frame
Start Date: 2024-04-22
Estimated Completion Date: 2026-01-08
Participants
Target number of participants: 47
Treatments
Study Participant
All participants of this study will be undergoing an autologous chondrocyte implantation of the knee for a chondral defect.
Related Therapeutic Areas
Sponsors
Leads: University of Manchester

This content was sourced from clinicaltrials.gov