The Impacts of Gluten Free Diet on Disease Activity, Quality of Life and Intestinal Permeability in Patients Diagnosed With Ankylosing Spondylitis.

Status: Recruiting
Location: See all (4) locations...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Subclinical intestinal inflammation and intestinal permeability have been reported in patients with ankylosing spondylitis. Gluten is one of the main triggers of zonulin releaseand gluten intake may contribute to the development of the disease by increasing intestinal permeability. This study aims to determine the impacts of a gluten-freediet on intestinal permeability, sub-clinical intestinal inflammation, disease activity, functional status and quality of life in patients with ankylosing spondylitis. The main questions it aims to answer are: Does a gluten-free diet have an effect on disease activity and functional status in patients with ankylosing spondylitis? Does a gluten-free diet have an effect on intestinal permeability and subclinical intestinal inflammation in patients with ankylosing spondylitis? The investigators will evaluate the effects of the gluten-free diet compared to a control group.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 64
Healthy Volunteers: f
View:

• diagnosis of axial SpA defined by ASAS criteria

• Adults (aged 18-64 years)

• stable treatment (NSAID and/or DMARD) for at least 3 months

• provide written informed consent and submit to the requirements of the study

Locations
Other Locations
Turkey
Bakırköy Dr. Sadi Konuk Training and Research hospital
RECRUITING
Istanbul
İstanbul Medeniyet University
ACTIVE_NOT_RECRUITING
Istanbul
İstanbul Sağlık Bilimleri University
ACTIVE_NOT_RECRUITING
Istanbul
Marmara University
ACTIVE_NOT_RECRUITING
Istanbul
Contact Information
Primary
Gülay Sezgin
dytgulaysezgin@gmail.com
+902124147171
Time Frame
Start Date: 2025-01-31
Estimated Completion Date: 2026-05-31
Participants
Target number of participants: 60
Treatments
No_intervention: Control Group
In the control arm, patients will continue their eating habits.
Experimental: Gluten Free Diet
Patients in the experimental arm will received a gluten-free diet for 8 weeks.
Related Therapeutic Areas
Sponsors
Leads: Saglik Bilimleri Universitesi

This content was sourced from clinicaltrials.gov