Extended Observational Study on the Long-term Impact of Tobramycin Inhalation Solution for Pseudomonas Aeruginosa Eradication in Patients With Bronchiectasis: The ERASE II Study

Status: Recruiting
Location: See all (58) locations...
Intervention Type: Other
Study Type: Observational
SUMMARY

The ERASE II study is a prospective follow-up study designed to assess the long-term impact of successful eradication of Pseudomonas aeruginosa (PA) in patients with bronchiectasis. Building on the findings of the initial ERASE study, which evaluated the efficacy and safety of Tobramycin Inhalation Solution, ERASE II aims to determine whether successful PA eradication influences patient prognosis over an extended period. The study will involve a total observation period of 36 months, consisting of the initial 9 months of the ERASE study followed by an additional 27 months of comprehensive follow-up. Key outcomes to be assessed include patients' quality of life, lung function, frequency of pulmonary exacerbations, frequency of hospitalization, and overall treatment costs. Additionally, the study will examine the timing and incidence of any potential reinfections with Pseudomonas aeruginosa.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 80
Healthy Volunteers: f
View:

• all patients who participate the ERSE study

• write the informed consent form.

Locations
Other Locations
China
The First People's Hospital of Anning City Affiliated to Kunming University of Science and Technology
RECRUITING
Anning
Beijing Chao-Yang Hospital, Capital Medical University
RECRUITING
Beijing
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences
RECRUITING
Beijing
The First Affiliated Hospital of Jilin University
RECRUITING
Changchun
The Second Xiangya Hospital of Central South University
RECRUITING
Changsha
Xiangya Hospital, Central South University
RECRUITING
Changsha
West China Hospital of Sichuan University
RECRUITING
Chengdu
The Second Affiliated Hospital of Chongqing Medical University
ACTIVE_NOT_RECRUITING
Chongqing
The Third Affiliated Hospital of Chongqing Medical University
RECRUITING
Chongqing
The Second Affiliated Hospital of Dalian Medical University
RECRUITING
Dalian
Fujian Provincial Hospital
RECRUITING
Fuzhou
The First Affiliated Hospital of Guangzhou Medical University
RECRUITING
Guangzhou
The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine
RECRUITING
Guangzhou
Guizhou Provincial People's Hospital
RECRUITING
Guiyang
Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University
ACTIVE_NOT_RECRUITING
Haikou
The Affiliated Hospital of Hangzhou Normal University
RECRUITING
Hangzhou
The Second Affiliated Hospital of Zhengjiang University
RECRUITING
Hangzhou
Anhui Chest Hospital
RECRUITING
Hefei
The First Affiliated Hospital of Anhui Medical University
RECRUITING
Hefei
Huzhou Central Hospital
RECRUITING
Huzhou
The First Hospital of Jiaxing City
RECRUITING
Jiaxing
The Second Hospital of Jiaxing City
ACTIVE_NOT_RECRUITING
Jiaxing
Qilu Hospital of Shandong University
RECRUITING
Jinan
The First Affiliated Hospital of Shandong First Medical University
ACTIVE_NOT_RECRUITING
Jinan
The First Affiliated Hospital of Kunming Medical University
ACTIVE_NOT_RECRUITING
Kunming
The First Affiliated Hospital of Nanchang University
RECRUITING
Nanchang
The Second Affiliated Hospital of Nanjing Medical University
RECRUITING
Nanjing
The First Affiliated Hospital of Guangxi Medical University
ACTIVE_NOT_RECRUITING
Nanning
Affiliated Hospital, Nantong University
RECRUITING
Nantong
The Sixth People's Hospital of Nantong City
RECRUITING
Nantong
Fenghua District People's Hospital of Ningbo City
RECRUITING
Ningbo
Ningbo Medical Center Lihuili Hospital
RECRUITING
Ningbo
The First Affiliated Hospital of Ningbo University
RECRUITING
Ningbo
Qingdao Municipal Hospital
RECRUITING
Qingdao
Baoshan District Hospital of Integrated Traditional Chinese and Western Medicine
RECRUITING
Shanghai
Ruijin Hospital
RECRUITING
Shanghai
Shanghai Eighth People's Hospital
RECRUITING
Shanghai
Shanghai General Hospital
RECRUITING
Shanghai
Shanghai pulmonary hospital
RECRUITING
Shanghai
Shanghai Putuo District People's Hospital
RECRUITING
Shanghai
Shanghai Sixth People's Hospital
RECRUITING
Shanghai
The Shanghai Fifth People's Hospital
RECRUITING
Shanghai
Zhongshan Hospital, Fudan University
RECRUITING
Shanghai
Shangrao People's Hospital
RECRUITING
Shangrao
Shengjing Hospital of China Medical University
RECRUITING
Shenyang
The First Affiliated Hospital of China Medical University
RECRUITING
Shenyang
Shenzhen Institute of Respiratory Diseases
RECRUITING
Shenzhen
The Eighth Affiliated Hospital of Sun Yat-Sen University
RECRUITING
Shenzhen
Suzhou Science and Technology Town Hospital
RECRUITING
Suzhou
The First Affiliated Hospital of Soochow University
RECRUITING
Suzhou
Shanxi Bethune Hospital
ACTIVE_NOT_RECRUITING
Taiyuan
The First Affiliated Hospital of Wenzhou Medical University
RECRUITING
Wenzhou
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
RECRUITING
Wuhan
Union Hospital,Tongji Medical College, Huazhong University of Science and Technology
RECRUITING
Wuhan
Subei People's Hospital
RECRUITING
Yangzhou
Affiliated Hospital, Guangdong Medical College
ACTIVE_NOT_RECRUITING
Zhanjiang
Henan Provincial People's Hospital
RECRUITING
Zhengzhou
Zhengzhou People's Hospital
RECRUITING
Zhengzhou
Contact Information
Primary
Jin-Fu Xu
jfxucn@163.com
+8613321922898
Backup
Jin-Fu Xu, PhD
jfxucn@163.com
+8613321922898
Time Frame
Start Date: 2024-10-16
Estimated Completion Date: 2027-12-31
Participants
Target number of participants: 364
Treatments
Patients who successfully eradicate Pseudomonas aeruginosa in ERASE study
no intervention
Patients who were not successful in eradicating Pseudomonas aeruginosa in the ERASE Study
No intervention
Related Therapeutic Areas
Sponsors
Leads: Shanghai Pulmonary Hospital, Shanghai, China

This content was sourced from clinicaltrials.gov