What is the definition of Bronchiectasis?

Bronchiectasis is a disease in which the large airways in the lungs are damaged. This causes the airways to become permanently wider.

Bronchiectasis can be present at birth or infancy or develop later in life.

What are the alternative names for Bronchiectasis?

Acquired bronchiectasis; Congenital bronchiectasis; Chronic lung disease - bronchiectasis

What are the causes for Bronchiectasis?

Bronchiectasis is often caused by inflammation or infection of the airways that keeps coming back.

Sometimes it begins in childhood after having a severe lung infection or inhaling a foreign object. Breathing in food particles can also lead to this condition.

Other causes of bronchiectasis can include:

  • Cystic fibrosis, a disease that causes thick, sticky mucus to build up in the lungs
  • Autoimmune disorders, such as rheumatoid arthritis or Sjögren syndrome
  • Allergic lung diseases
  • Leukemia and related cancers
  • Immune deficiency syndromes
  • Primary ciliary dyskinesia (another congenital disease)
  • Infection with non-tuberculous mycobacteria

What are the symptoms for Bronchiectasis?

Symptoms develop over time. They may occur months or years after the event that causes the bronchiectasis.

Long-term (chronic) cough with large amounts of foul smelling sputum is the main symptom of bronchiectasis. Other symptoms may include:

  • Breath odor
  • Coughing up blood (less common in children)
  • Fatigue
  • Paleness
  • Shortness of breath that gets worse with exercise
  • Weight loss
  • Wheezing
  • Low grade fever and night sweats
  • Clubbing of fingers (rare, depends on cause)

What are the current treatments for Bronchiectasis?

Treatment is aimed at:

  • Controlling infections and sputum
  • Relieving airway blockage
  • Preventing the problem from becoming worse

Daily drainage to remove sputum is part of treatment. A respiratory therapist can show the person coughing exercises that will help.

Medicines are often prescribed. These include:

  • Antibiotics to treat infections
  • Bronchodilators to open up airways
  • Expectorants to help loosen and cough up thick sputum

Surgery to remove (resect) the lung may be needed if medicine does not work and the disease is in a small area, or if the person has a lot of bleeding in the lungs. It is more commonly considered if there is no genetic or acquired predisposition to bronchiectasis (for example, more likely to consider if there is bronchiectasis in one segment of the lung only because of prior obstruction).

What is the outlook (prognosis) for Bronchiectasis?

The outlook depends on the specific cause of the disease. With treatment, most people live without major disability and the disease progresses slowly.

What are the possible complications for Bronchiectasis?

Complications of bronchiectasis may include:

  • Cor pulmonale
  • Coughing up blood
  • Low oxygen levels (in severe cases)
  • Recurrent pneumonia
  • Depression (in rare cases)

When should I contact a medical professional for Bronchiectasis?

Call your provider if:

  • Chest pain or shortness of breath gets worse
  • There is a change in the color or amount of phlegm you cough up, or if it is bloody
  • Other symptoms get worse or do not improve with treatment

How do I prevent Bronchiectasis?

You can reduce your risk by promptly treating lung infections.

Childhood vaccines and a yearly flu vaccine help reduce the chance of some infections. Avoiding upper respiratory infections, smoking, and pollution may also reduce your risk of getting this infection.

Lungs
Respiratory

REFERENCES

Chan ED, Iseman MD. Bronchiectasis. In: Broaddus VC, Mason RJ, Ernst JD, et al, eds. Murray and Nadel's Textbook of Respiratory Medicine. 6th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 48.

Chang AB, Redding GJ. Bronchiectasis and chronic suppurative lung disease. In: Wilmott RW, Deterding R, Li A, et al, eds. Kendig's Disorders of the Respiratory Tract in Children. 9th ed. Philadelphia, PA: Elsevier; 2019:chap 26.

O'Donnell AE. Bronchiectasis, atelectasis, cysts, and localized lung disorders. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 84.

James D. Chalmers
JC
Elite
James D. Chalmers
Dundee, GB
Stefano Aliberti
SA
Elite
Stefano Aliberti
IT
Michael R. Loebinger
ML
Elite
Michael R. Loebinger
GB
Adam T. Hill
AH
Elite
Adam T. Hill
Edinbugh, GB
AS
Elite
Amelia Shoemark
Dundee, SCT, GB
Eva Polverino
EP
Elite
Eva Polverino
Barcelona, CT, ES
  • Condition: Patient Supported with Extracorporeal Membrane Oxygenation (ECMO) after COVID-19 in Poland
  • Journal: Advances in respiratory medicine
  • Treatment Used: Lung Transplantation (LTx)
  • Number of Patients: 1
  • Published —
This case report describes a 44-year-old male supported with extracorporeal membrane oxygenation (ECMO) after COVID-19 in Poland who underwent lung transplantation.