Optimizing Periinterventional Coagulation Management of Patients Undergoing a Transjugular Intrahepatic Portosystemic Shunt Implantation: A Prospective Randomized Cohort Study
Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
Assess whether a pre-interventional thrombelastography guided algorithm for assessing and correction of coagulation status in cirrhotic patients is safe and effective
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Liver cirrhosis
• \>18 years
• Indication for TIPS implantation
Locations
Other Locations
Austria
Department of Internal Medicine, Medical University of Graz
RECRUITING
Graz
Time Frame
Start Date: 2020-05-27
Estimated Completion Date: 2027-05
Participants
Target number of participants: 39
Treatments
Experimental: Thrombelastogram (TEG)
Patients in the TEG group will receive prothrombin complex concentrates (PCC) at a dose of 10 IE/kg of ideal body weight, when R-time was greater than 40 minutes (2400 sec) and they will receive platelet transfusion in the amount of 1 apheresis unit when MA was below 30 mm.
Experimental: Standard of Care (SOC)
In the SOC group, patients will receive PCC at the dose of 10 IE /kg of ideal body weight when the PT is below 50% and/or INR\>1.8 and/or received platelet transfusion in the amount of 1 apheresis when platelet count is below 50 G/L
Related Therapeutic Areas
Sponsors
Leads: Medical University of Graz