Volatile Organic Compounds for the Assessment of Liver Disease: Assessment of Hepatobiliary Disease Through Non-Invasive Detection of Exhaled Volatile Organic Compounds

Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Observational
SUMMARY

This study aims to determine whether a breath test could be used for early detection of hepatic fibrosis, cirrhosis or hepatocellular carcinoma. Patients who are attending for a planned liver outpatient services or investigations will be approached to provide a breath sample. Multi platform mass spectrometry analysis will be performed to establish volatile biomarkers that can discriminate between fibrosis, cirrhosis and hepatocellular carcinoma.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 90
Healthy Volunteers: t
View:

• Patients seen in secondary care with suspected or confirmed liver / pancreatic disease or hepatocellular carcinoma / pancreatic cancer

• Patients able to understand and retain the information provided, thereby being able to give informed consent for inclusion in this study

Locations
Other Locations
United Kingdom
Imperial College Healthcare Trust
RECRUITING
London
Contact Information
Primary
Michael J Hewitt, MBBS BSc
michael.hewitt06@imperial.ac.uk
02033126328
Time Frame
Start Date: 2021-04-01
Estimated Completion Date: 2025-09
Participants
Target number of participants: 500
Treatments
Controls
Healthy Controls with or without risk factors for Chronic Liver Disease (i.e. patients referred due to concerns re: liver disease but found to have no evidence of chronic liver disease following assessment)
Fibrosis
Patients with evidence of Liver Fibrosis on the basis of current diagnostic techniques / expert opinion.
Compensated Cirrhosis
Patients with evidence of Compensated Cirrhosis on the basis of current diagnostic techniques / expert opinion.
Decompensated Cirrhosis
Patients with evidence of Decompensated Cirrhosis on the basis of current diagnostic techniques / expert opinion.
Hepatocellular Carcinoma
Patients with evidence of Hepatocellular Carcinoma on the basis of current diagnostic techniques / expert opinion.
Related Therapeutic Areas
Sponsors
Leads: Imperial College London

This content was sourced from clinicaltrials.gov