The Incidence, Risk Factors and Outcome of Postoperative Delirium in Elderly Patients Undergoing Non-cardiac Surgery: a Prospective Observational Study

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Drug
Study Type: Observational
SUMMARY

Postoperative delirium (POD) is the most common adverse neurologic complication that can occur in patients of any age. Its incidence varies across age groups and is substantially influenced by patient-related risk factors. POD occurs in 17%-61% of major surgical procedures. Several risk factors which contribute to the development of POD include age more than 60 years, pre-existing cognitive dysfunction, presence of comorbidities, sensorial deficits, malnutrition, polypharmacy, impaired physical mobility and frailty. Postoperative delirium has several wide ranging and adverse outcomes that are consistently associated with delirium such as mortality, increased length of hospital stay, and increased hospital costs. A recently devised tool for rapid assessment of delirium is the 4 A's test. It has now been validated for identifying delirium in the surgical population. The proposed prospective observational study will be conducted on 150 patients belonging to ASA Physical Status I-III of either sex, scheduled to undergo non-cardiac surgery under general anaesthesia (GA), requiring at least 24 hours of postoperative inpatient care. This prospective, observational study aims to evaluate the incidence, risk factors and outcomes of postoperative delirium in elderly patients more than 65 years of age undergoing non-cardiac surgery.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 65
Healthy Volunteers: f
View:

• Patients of age \>65yrs

• Either sex

• ASA physical status I - III

• Elective non-cardiac surgical procedures under general anesthesia

• Clinical Frailty Score (CFS): 1-8

• Patients requiring at least 24 hours of postoperative inpatient care.

Locations
Other Locations
India
Sir Ganga Ram Hospital
NOT_YET_RECRUITING
New Delhi
Sir Ganga Ram Hospital
RECRUITING
New Delhi
Contact Information
Primary
Bimla Sharma, MBBS, DGO, MD, FICA, MHA
bimsharma1@gmail.com
00911142252523
Backup
Nitin Sethi, MBBS, DNB
nitinsethi77@yahoo.co.in
00911142252523
Time Frame
Start Date: 2021-01-14
Estimated Completion Date: 2026-09
Participants
Target number of participants: 270
Treatments
Elderly
Patients \> 65 years age undergoing non-cardiac surgery will be administered general anesthesia maintained with sevoflurane or desflurane titrated to maintain anaesthesia depth of 50 (BIS score) using bispectral (BIS) index monitioring
Related Therapeutic Areas
Sponsors
Leads: Sir Ganga Ram Hospital

This content was sourced from clinicaltrials.gov