Intraoperative Infusion of Dexmedetomidine for Prevention of Postoperative Delirium in Elderly Patients Undergoing Craniotomy: a Randomized Clinical Trial
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
Postoperative delirium (POD) is a common surgical complication. The incidence is 10% to 22% in neurological procedures, and advanced age is a risk factor for neurological procedures. Many studies have shown that dexmedetomidine(DEX) may reduce the incidence of delirium in non-cardiac surgery patients and elderly patients. However, there are few studies focus on the effect of DEX on POD in elderly patients undergoing neurosurgery. The purpose of this study was to investigate the effect of DEX on POD in in elderly patients undergoing craniotomy.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 65
Healthy Volunteers: f
View:
• Patients undergoing selective craniotomy.
• Age ≥65 years.
• Obtain written informed consent.
Locations
Other Locations
China
Beijing Tian Tan Hospital, Capital Medical University
RECRUITING
Beijing
Contact Information
Primary
Yuming Peng, MD,Ph.D
florapym766@163.com
8610-59976658
Time Frame
Start Date: 2022-07-18
Estimated Completion Date: 2025-12-30
Participants
Target number of participants: 420
Treatments
Active_comparator: DEX group
The DEX group patients will be received dexmedetomidine intraoperatively.
Placebo_comparator: Placebo group
The placebo group patients will be received 0.9% saline intraoperatively.
Related Therapeutic Areas
Sponsors
Leads: Beijing Tiantan Hospital