Effect of Remimazolam and Propofol on Postoperative Delirium in Elderly Patients Undergoing Hip and Knee Surgery

Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Remimazolam is an ultra-short acting benzodiazepine agonist which is used widely for general anesthesia and sedation. Remimazolam has several advantages. Remimazolam is rapidly metabolized by tissue esterase that it does not accumulate even after infusion for long periods of time. The presence of reversal agents (flumazenil) is also advantageous. Also, hemodynamic stability compared to propofol gives clinicians preference to use for geriatric anesthesia. However, the study on the effect of remimazolam compared to propofol on postoperative delirium have not been carried out. The purpose of the study is to compare the incidence of postoperative delirium and recovery profile in elderly patients undergoing orthopedic surgery using either remimazolam or propofol.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 65
Maximum Age: 100
Healthy Volunteers: t
View:

• elderly patients undergoing hip or knee arthroplasty under general anesthesia.

• body mass index \>30 kg/m2

Locations
Other Locations
Republic of Korea
Sanggye Paik hospital
RECRUITING
Seoul
Contact Information
Primary
In-Jung Jun, MD PhD
christine17@hanmail.net
82-10-9312-0162
Time Frame
Start Date: 2022-08-01
Estimated Completion Date: 2025-12-31
Participants
Target number of participants: 82
Treatments
Experimental: Remimazolam group
Remimazolam is started during induction of anesthesia at the rate of 6 mg/kg/hr and continued at the rate of 1 mg/kg/hr (within 0.3-2 mg/kg/hr). Remimazolam is stopped 20 minutes before end of operation.
Active_comparator: Propofol group
Propofol is continuously infused within 1-5 μg/mL.
Related Therapeutic Areas
Sponsors
Leads: Inje University

This content was sourced from clinicaltrials.gov