Effect of General Anesthesia With Remimazolam Versus Propofol on Postoperative Delirium in Elderly Patients
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
Remimazolam is a novel benzodiazepine with ultra-short onset and offset of its effect. It can be used for general anesthesia. However, classical benzodiazepine such as midazolam was reported to increase the risk of postoperative delirium. Thus, the investigators aim to investigate the effect of remimazolam general anesthesia on postoperative delirium in elderly patients.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 65
Healthy Volunteers: f
View:
• Age ≥65 years
• patients scheduled for elective surgery under general anesthesia
Locations
Other Locations
China
Xijing hospital, Fourth military medical university
RECRUITING
Xi'an
Contact Information
Primary
Zhihong Lu
deerlu23@163.com
+8613891975018
Time Frame
Start Date: 2022-05-25
Estimated Completion Date: 2024-01-30
Participants
Target number of participants: 190
Treatments
Experimental: remimazolam
remimazolam continuous infusion is used for general anesthesia; dosage:0.7-1.5mg/kg/h; duration: from start of anesthesia induction to end of surgery
Active_comparator: propofol
propofol continuous infusion is used for general anesthesia; dosage:4-8mg/kg/h; duration: from start of anesthesia induction to end of surgery
Related Therapeutic Areas
Sponsors
Leads: Zhihong LU