Prevalence of Cognitive Disorders in Newly Diagnosed Epilepsy

Status: Recruiting
Location: See location...
Intervention Type: Behavioral
Study Type: Observational
SUMMARY

A prospective prevalence study recorded that up to 50% of adult patients with newly diagnosed epilepsy had at least one cognitive impairment before initiation of antiepileptic drug (AED). Multiple factors exist and interact in the same patient. Cognitive impairments may affect psychiatric (loss of self-esteem, anxiety, depression) and social status (e.g., vocational aptitude, educational). These factors in turn influence cognitive abilities in a triangular and bidirectional relationship. In addition, the type of epilepsy, development in childhood or cerebral ageing, antiepileptic treatments (AED, surgery) and etiology also have an impact on cognitive performances. The burden of these factors differs from patient to another and must be determined individually. Longitudinal follow-up seems to be crucial because it will allow us to highlight the change in the cognitive profile of newly diagnosed patients over time. The main objective is to compare the prevalence of cognitive impairment in patients with newly diagnosed epilepsy prior to the initiation of AED with healthy subjects matched on age, sex, manual laterality and socio-educational level. But also to compare the longitudinal evolution of the cognitive profile of patients with healthy controls (0 to 10 years) to determine, among the age of onset seizures, their etiology, the syndrome, the sex, the socio-educational level and the cognitive reserve, which one are related to the severity of cognitive disorders.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 16
Healthy Volunteers: t
View:

• Individuals who have received full information about the organization of the research and have not refused to participate and to use their data.

• Person aged 16 and over

• For minor patients: the non-opposition of the parental authority holders

• Newly diagnosed epileptic patient who had never taken antiepileptic drugs.

• Individuals who have received full information about the organization of the research and have not refused to participate and to use their data.

• For minor participants: the non-opposition of the parental authority holders

• Person aged 16 and over.

Locations
Other Locations
France
Department of neurology - Hospital of Nancy
RECRUITING
Nancy
Contact Information
Primary
Natacha Forthoffer
n.forthoffer@chru-nancy.fr
03.83.85.20.77
Time Frame
Start Date: 2021-02-17
Estimated Completion Date: 2026-02-01
Participants
Target number of participants: 300
Treatments
Newly diagnosed epileptic patients
Newly diagnosed epileptic patients who have never be treated by antiepileptic drugs and who have no psychiatric (mental illness) and/or evolutive neurological history and for minor patients the non-opposition of the parental authority holders.
Normal controls
Matched (on age, gender, socio-educationnal level and manual laterality) healthy controls who have no psychiatric (depression, mental illness) and/or neurological (stroke, traumatic brain injury, etc.) history and for minor patients the non-opposition of the parental authority holders.
Related Therapeutic Areas
Sponsors
Leads: Central Hospital, Nancy, France

This content was sourced from clinicaltrials.gov