Electrical Stimulation for Seizure Induction in Pediatric Drug-Refractory Epilepsy (ESIS in Pedriatric DRE).

Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY

The main reason for this research study is to gain information about how the brain makes seizures by causing seizures using very small amounts of current, or electrical stimulation. Using small amounts of current to cause seizures (or stimulate) is not new at CCHMC - it is part of routine clinical practice for some patients at some electrodes. This study differs from routine clinical care in that all study patients will undergo electrical stimulation in all or nearly all electrode contacts. The study team is doing this because there is promising data in adult patients that stimulating comprehensively (targeting all or nearly all of the electrode contacts) helps define the seizure network. Defining the seizure network in turn helps the medical team plan surgery. So far, there is not as much published data on seizure stimulation for pediatric patients. This research study thus has the potential both to help individual patients (by providing specific information about your seizure networks) and to help pediatric patients with epilepsy in general (by increasing our understanding of stimulated seizures in children, teenagers and young adults).

Eligibility
Participation Requirements
Sex: All
Minimum Age: 1
Maximum Age: 30
Healthy Volunteers: f
View:

• Diagnosis of drug-refractory epilepsy (DRE)

• 1-30 years of age

• recommended to undergo stereoencephalography (sEEG) at CCHMC

Locations
United States
Ohio
Cincinnati Children's Hospital Medical Center
RECRUITING
Cincinnati
Contact Information
Primary
Sarah Katie Ihnen, MD, PhD
Katie.Ihnen@cchmc.org
5136364222
Backup
Molly S Griffith, BA
molly.griffith@cchmc.org
15136369669
Time Frame
Start Date: 2022-02-17
Estimated Completion Date: 2027-12-31
Participants
Target number of participants: 86
Related Therapeutic Areas
Sponsors
Collaborators: Network for Excellence in Neuroscience Clinical Trials, Child Neurologist Career Development Program
Leads: Sarah Katie Ihnen

This content was sourced from clinicaltrials.gov