Human Intracranial Electrophysiology

Status: Recruiting
Location: See location...
Intervention Type: Other, Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This study will enroll patients with epilepsy who are being evaluated for epilepsy surgery and have electrodes implanted in the brain and/or have electrodes on the scalp. Additionally, this study will recruit normal and online controls (participants who do not have epilepsy). Participants will be asked to participate in 1 to 2 (30-90 minutes) daily sessions designed to test aspects of human cognition such as memory, speech, language, feeling, movement, attention, sound perception, and emotions. Generally, this will involve working on a computer, looking at pictures or watching videos, and answering questions. Additionally, participants may be asked to be hooked up to additional equipment such as eye tracker, electrical stimulator, heart rate monitor, sweat monitor or other non-invasive equipment. The overall aim of this study is to use human intracranial electrophysiology (the recording of the electrical activity of the human brain) to study localization and function of the human brain.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: t
View:

• Patients must be age 18 years or older. There is no upper age limit.

• Patients must have a diagnosis of refractory epilepsy undergoing intracranial EEG recording for clinical purposes.

• Patients must be age 18 years or older. There is no upper age limit.

• Patients must have a probable diagnosis of epilepsy.

• Participants must be age 18 years or older. There is no upper age limit.

• Participants must be able to provide informed consent for themselves.

Locations
United States
New Hampshire
Dartmouth-Hitchcock Medical Center
RECRUITING
Lebanon
Contact Information
Primary
Krzysztof A Bujarski, MD
krzysztof.a.bujarski@hitchcock.org
603-650-5104
Backup
Anastasia Kanishcheva, MPH
Anastasia.Kanishcheva@Hitchcock.ORG
603-650-0260
Time Frame
Start Date: 2023-01-17
Estimated Completion Date: 2032-08-01
Participants
Target number of participants: 175
Treatments
Experimental: Invasive EEG (electrodes are implanted in a participant's brain)
Patients with intracranial electrodes (electrodes are implanted in a participant's brain) undergoing pre-surgical evaluation for clinical reasons will be asked to participate in various study tasks with the recording of intracranial EEG (recording of brain waves via electrodes implanted in a participant's brain) during these tasks.
Experimental: Scalp EEG (electrodes are placed on a participant's scalp)
Patients with non-invasive scalp electrodes who are admitted to the hospital for clinical reasons will be asked to participate in various study tasks with the recording of their EEG (recording of brain waves via electrodes attached to a participant's scalp) during these tasks.
Active_comparator: Normal Controls
Normal controls will be recruited from family members of patients, from advertisements, or from online tools. There will be no EEG recordings obtained from these participants.
Active_comparator: Online Controls
Certain control subjects will be recruited through Amazon Mechanical Turk. These participants will be given their task on the online platform using Qualtric survey function. The task design will be identical to normal controls who are recruited in-person, with the exception of identifiers. There will be no EEG recordings obtained from these participants.
Related Therapeutic Areas
Sponsors
Collaborators: Dartmouth College
Leads: Dartmouth-Hitchcock Medical Center

This content was sourced from clinicaltrials.gov

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