Cartography of Social Cognition Network and Their Alterations in Patients With Epilepsy

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Radiation
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Social cognition, which refers to the ability to interpret social information and behave accordingly in a social environment, is crucial in everyday life. But this ability has been shown to be altered in patients with epilepsy, especially in medial temporal lobe epilepsy, which leads to a deterioration in the patient's quality of life. However, the mechanisms of those deficiencies remain largely unknown. The Team objective is to achieve a structural and functional cartography of the social cognition network in 20 healthy subjects and 20 patients with drug-resistant medial temporal lobe epilepsy (before and one year after resective surgery of the epileptogenic focus). Social cognition deficiencies will be assessed using a specifically dedicated neuropsychological assessment validated in French (Batteries de Cognition Sociale BCS). Brain structural analyses will be performed on a 3-Tesla MRI (3T MRI), including an anatomical T1 sequence, a High Angular Resolution Diffusion Imaging (HARDI) to assess the morphology and macrostructural characteristics of long and short white matter tracts involved in social cognition, and quantitative MRI and Hybrid Diffusion Imaging (HYDI) to assess their microstructure. Functional connectivity will be assessed using an ultra-high-field 7-Tesla MRI (7T MRI), with acquisition in resting state and during specific social cognition tasks. Joint analysis of structural and functional connectivity will enable the team to assess the alterations of social cognition networks in patients with epilepsy and their reorganisations after epilepsy surgery.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 65
Healthy Volunteers: f
View:

• Age ≥ 18 years old

• Good understanding of written and verbal French language

• Written consent signed by the subject

• Patients with focal temporal lobe epilepsy for at least one year, drug-resistant, due to a hippocampal sclerosis

• Undergoing presurgical assessment

• Affiliated to a social security system

Locations
Other Locations
France
NeuroSpin - CEA
ACTIVE_NOT_RECRUITING
Gif-sur-yvette
Unité d'épilepsie - GHU Pitié Salpêtrière
RECRUITING
Paris
Contact Information
Primary
Bastien HERLIN, MD, PH
bastien.herlin@php.fr
1 42 16 03 01
Backup
Sophie DUPONT, MD,PHD
sophie.dupont@aphp.fr
1 42 16 03 01
Time Frame
Start Date: 2025-03-19
Estimated Completion Date: 2029-01-19
Participants
Target number of participants: 20
Treatments
Experimental: Patients with focal temporal lobe epilepsy for at least one year, drug-resistant
Related Therapeutic Areas
Sponsors
Leads: Assistance Publique - Hôpitaux de Paris

This content was sourced from clinicaltrials.gov