The Computational and Neural Mechanisms Linking Decision-making and Memory in Humans

Status: Recruiting
Location: See location...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Learning to make good decisions in the present, and accurately recalling events and information from the past, are critical aspects of human cognition that are often impaired in many psychiatric disorders. This project aims to identify the how the choices individuals make influence what, and how, people remember by combining disparate techniques in computational modeling and direct brain recordings in human subjects. The researcher developed a dual-task paradigm, probing how decisions in one task affect immediate recognition memory. To examine the neural mechanisms underlying model-free RL's influence on memory, the researcher will record local field potential (LFP) and single neuron activity in various brain regions as epilepsy patients perform the proposed task. The results of this project will identify specific neurocomputational mechanisms unifying decision-making and memory processes.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 65
Healthy Volunteers: f
View:

• Has seizure activity which is deemed non-responsive to standard pharmacological intervention(s), as determined by treating Neurologist and established clinical practices

• Has elected to receive clinically indicated intracranial EEG (electrocorticography (ECoG), stereoelectroencephalography (SEEG)) and/or temporal responsive neurostimulation (RNS) for medication-refractory epilepsy outside of this research study, as determined by treating clinician(s) and per current clinical practice

• Capacity to provide written informed consent

• Language proficiency in English or Spanish

• Willing and able to comply with all study-related procedures

Locations
United States
New York
Mount Sinai West
RECRUITING
New York
Contact Information
Primary
Salman E Qasim, PhD
salman.qasim@mssm.edu
212-824-9531
Time Frame
Start Date: 2023-10-31
Estimated Completion Date: 2028-09-01
Participants
Target number of participants: 50
Treatments
Experimental: Value-manipulation
Participants with epilepsy will complete a behavioral task in which they use a laptop computer to do a decision-making and memory task.
Related Therapeutic Areas
Sponsors
Leads: Rutgers, The State University of New Jersey
Collaborators: National Institute of Mental Health (NIMH)

This content was sourced from clinicaltrials.gov