Investigating the Functional Characteristics During Wakefulness and Sleep Based on SEEG
Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
This study aims to collect electrophysiological and clinical data from patients aged 14-65 with drug-resistant epilepsy who underwent SEEG. The collected data will be analyzed to investigate the functional connectivity during wakefulness and sleep states.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 14
Maximum Age: 65
Healthy Volunteers: f
View:
• Drug-resistant focal epilepsy
• Justified SEEG exploration in the context of presurgical assessment of epilepsy
• Subjects will be a part of the epilepsy-monitoring unit for long-term SEEG recordings and analysis
• Written non-opposition to study participation
Locations
Other Locations
China
Xuanwu Hospital, Beijing
RECRUITING
Beijing
Contact Information
Primary
Liankun Ren, MD
renlk2022@outlook.com
13681576621
Time Frame
Start Date: 2024-07-08
Estimated Completion Date: 2027-10-08
Participants
Target number of participants: 20
Treatments
Experimental: SEEG recordings and SPES effects
Single-pulse electrical stimulation (SPES) evokes transient neuronal responses that propagate through functional networks, providing a powerful tool to map brain connectivity. When delivered at low frequencies (0.05 Hz, every 20 s), SPES allows quantitative assessment of dynamic network interactions while avoiding long-term synaptic modifications. These stimulation-induced responses, recorded via stereoelectroencephalography (SEEG), reveal both local and distributed neural activity with millisecond precision.
Related Therapeutic Areas
Sponsors
Leads: Xuanwu Hospital, Beijing