Spatial Memory and Temporal Lobe Epilepsy

Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Temporal lobe epilepsy (TLE) can cause memory disorders, including long-term forgetfulness due to a failure to consolidate verbal but also spatial information. The forgetting phenomenon presented by these epileptic patients is called accelerated forgetting in the literature and remains difficult to objectify during cognitive assessments. It is indeed particularly complicated to evaluate long-term spatial memory and to account for the topographical complaint, although recurrent, of patients with this TLE. A navigation task being proposed as part of the neuropsychological assessment of patients with a spatial memory complaint, it is interesting to study the performance pattern of patients with TLE by comparing them to a group of control subjects matched in age and gender in order to verify whether there is significant long-term forgetting and whether there is a significant difference between Right TLE and Left TLE. Indeed, several studies have demonstrated this accelerated long-term forgetting in epileptic patients (Cassel et al., 2016; Lemesle et al., 2017; Landry et al., 2022; Blake et al., 2020) but few with a retention delay of several weeks (Tramoni et al., 2009). This study allows us to statistically analyze the effects of these two groups: epileptic patients and healthy volunteers, but also to combine the effect of the laterality of epilepsy specifically on spatial memory performance.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: t
View:

∙ \- healthy volunteers meeting each of the following criteria:

• Aged over 18 years

• Right-handed\*

• Free of known neurological pathology

• Signed consent

• Matched in age (+ or - 5 years) and gender with epileptic patients presenting the characteristics below:

‣ Right-handed\*

⁃ adult

⁃ presenting temporal lobe epilepsy, whose lateralization of the epileptogenic focus (right or left) has been objectified by an examination (EEG and/or MRI),

⁃ having carried out a neuropsychological assessment including the navigation task,

⁃ having been informed of the study, and consenting to the processing of their data

Locations
Other Locations
France
Centre Hospitalier Métropole Savoie
RECRUITING
Chambéry
Contact Information
Primary
Jacqueline BOUCHET
jacqueline.bouchet@ch-metropole-savoie.fr
+33479965161
Backup
Fabienne Prieur
fabienne.prieur@ch-metropole-savoie.fr
+33479965999
Time Frame
Start Date: 2025-02-26
Estimated Completion Date: 2025-11-12
Participants
Target number of participants: 37
Treatments
Experimental: Healthy participant
spatial memory test to healthy participant
Experimental: Epileptic patient
spatial memory test to epileptic patient
Related Therapeutic Areas
Sponsors
Leads: Centre Hospitalier Metropole Savoie

This content was sourced from clinicaltrials.gov