Investigation of Interictal Metabolic and Electrophysiologic Changes in Epilepsy Through Trimodal Neuroimaging

Status: Recruiting
Location: See location...
Intervention Type: Radiation
Study Type: Observational
SUMMARY

This study aims to better understand how epilepsy alters brain function through neuroimaging of healthy people and people with epilepsy. The study investigates how changes in brain metabolism (sugar consumption, measured by positron emission tomography \[FDG-PET\], and blood flow, measured by functional magnetic resonance imaging \[fMRI\]) relate to abnormal interictal electrical activity associated with epilepsy (measured by electroencephalography \[EEG\]). The study will also compare how the three imaging modalities localize regions of abnormal function in the brain.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: t
View:

• Age 18 or older

⁃ Additional Inclusion Criteria for Subjects with Epilepsy:

• Diagnosed with epilepsy with abnormal interictal EEG

Locations
United States
Massachusetts
Athinoula A. Martinos Center
RECRUITING
Charlestown
Contact Information
Primary
Magdelena S Allen, BA
mallen27@mgh.harvard.edu
617-724-9232
Time Frame
Start Date: 2023-09-21
Estimated Completion Date: 2025-11-30
Participants
Target number of participants: 30
Treatments
Healthy Controls
Healthy control subjects with no major medical history
Subjects with Epilepsy
Subjects diagnosed with epilepsy and with abnormal electrical activity recorded on interictal EEG.
Related Therapeutic Areas
Sponsors
Leads: Massachusetts General Hospital

This content was sourced from clinicaltrials.gov