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Human Hippocampal Oscillations During Visuomotor Exploration

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The objective of this study is to determine how visuomotor exploration relates to hippocampal activity along its long axis. The study will investigate the neurophysiological mechanisms in the hippocampus during (1) visual exploration in surgical patients using high-resolution iEEG, and (2) ambulatory exploration in patients implanted with RNS devices.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 70
Healthy Volunteers: t
View:

⁃ All subjects:

• Adults (18-70 years)

• Able to provide informed consent

⁃ Aim 1: Surgical epilepsy patients' inclusion criteria

• Implanted hippocampal depth electrodes for Stage 1 epilepsy surgery

• IQ=\>80\*

⁃ Aim 2: RNS patients Inclusion criteria

• Implanted RNS device with at least one hippocampal depth electrode

• At least 5 months post-implantation to avoid the post-implant effect

• Have a relatively low number of seizures, defined as =\<1 debilitating seizure per week

• Able to walk and wear research equipment without assistance

• IQ\>=80

⁃ Aim 2: Healthy Control Inclusion criteria • Able to walk and wear research equipment without assistance

Locations
United States
New York
NYU Langone Health
RECRUITING
New York
Contact Information
Primary
Anli Liu, MD, MA
Anli.Liu@nyulangone.org
(929) 455-2323
Backup
Ayelet Rosenberg
Ayelet.rosenberg@nyulangone.org
(646) 558-0893
Time Frame
Start Date: 2026-02-25
Estimated Completion Date: 2028-10-08
Participants
Target number of participants: 56
Treatments
Experimental: Epilepsy Surgery Patients
Aim 1: Participants will be presented with between 10-15 unique immersive virtual environments (depending on patient tolerance) for patients to explore using VR glasses. Control tasks will be run to account for eye movements during non-navigation. For recording eye movements in darkness during REM sleep, as part of a control task, 4 electrodes will be placed above and below both eyes, a standard technique in polysomnographic studies.
Experimental: Patients with RNS Devices
Aim 2: Participants will walk between 4-6 rooms within an office floor. Each office will contain generic objects (office furniture, computers, lighting) and unique objects (artwork, photographs, books, and personal items). As control conditions, subjects will first be asked to walk around and between two empty rooms under different lighting conditions and speeds. Participants will also be asked to participate in all awake saccade control conditions (without a visual cognitive load).
Experimental: Healthy Control Participants
Aim 2: Participants will walk between 4-6 rooms within an office floor. Each office will contain generic objects (office furniture, computers, lighting) and unique objects (artwork, photographs, books, and personal items). As control conditions, subjects will first be asked to walk around and between two empty rooms under different lighting conditions and speeds. Participants will also be asked to participate in all awake saccade control conditions (without a visual cognitive load).
Related Therapeutic Areas
Epilepsy
Sponsors
Leads: NYU Langone Health
Collaborators: National Institute on Deafness and Other Communication Disorders (NIDCD)

This content was sourced from clinicaltrials.gov

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