Epilepsy Clinical Trials

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Evaluating Efficacy and Tolerability of Three Times Daily Levetiracetam in Epilepsy Patients

Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 3
SUMMARY

The purpose of this clinical trial is to evaluate the efficacy and tolerability of Levetiracetam administered three times daily in patients with epilepsy. The primary objective is to investigate whether orally administered Levetiracetam three times daily dosing is superior in seizure-free days compared to standard twice-daily dosing in patients with epilepsy. Key questions include: * Does LEV improve seizure control, as measured by seizure-free days? * What adverse events or safety concerns are observed with LEV treatment? Participants will receive Levetiracetam administered three times daily during the treatment phase. The study will use a self-matched, pre-post design in which each participant serves as their own control. Baseline seizure activity and safety data will be collected prior to LEV initiation and compared with data obtained during the treatment period. Participants will attend scheduled clinic visits for efficacy and safety evaluations and will maintain a daily diary to record seizure frequency and any treatment-related events.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Aged 18 years or older.

• diagnosed with uncontrolled Epilepsy of any type (defined as one or more unprovoked seizures in the last 6 months)

• On Levetiracetam monotherapy

• Participants must have a documented history of Levetiracetam use for at least 12 months prior to enrollment.

• on Levetiracetam high dose (1.5 - 3 g daily)

Locations
Other Locations
Saudi Arabia
King Saud University
RECRUITING
Riyadh
Time Frame
Start Date: 2025-10-01
Estimated Completion Date: 2028-12-30
Participants
Target number of participants: 120
Treatments
Active_comparator: Levetiracetam BID
Levetiracetam (750mg - 1500 mg) oral tablet twice times a day for 12 months
Related Therapeutic Areas
Sponsors
Leads: Waad Alkathiri

This content was sourced from clinicaltrials.gov