Learn About Hereditary Pancreatitis
Hereditary pancreatitis is a genetic condition characterized by recurrent episodes of inflammation of the pancreas (pancreatitis). The pancreas produces enzymes that help digest food, and it also produces insulin, a hormone that controls levels of blood glucose, also called blood sugar. Episodes of pancreatitis can lead to permanent tissue damage and loss of pancreatic function.
Mutations in the PRSS1 gene cause most cases of hereditary pancreatitis. The PRSS1 gene provides instructions for making an enzyme called cationic trypsinogen. This enzyme is produced in the pancreas and helps with the digestion of food. When cationic trypsinogen is needed, it is released (secreted) from the pancreas and transported to the small intestine, where it is cut (cleaved) into its working or active form called trypsin. When digestion is complete and trypsin is no longer needed, the enzyme is broken down.
Hereditary pancreatitis is thought to be a rare condition. In Europe, its prevalence is estimated to be 3 to 6 per million individuals.
When hereditary pancreatitis is caused by mutations in the PRSS1 gene, it is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder. In some cases, an affected person inherits the PRSS1 gene mutation from one affected parent. Other cases result from new mutations in the gene and occur in people with no history of the disorder in their family.
Duke Endoscopy Clinic - Clinic 2H
Darshan Kothari is a Gastroenterologist in Durham, North Carolina. Dr. Kothari is rated as an Elite provider by MediFind in the treatment of Hereditary Pancreatitis. His top areas of expertise are Hereditary Pancreatitis, Chronic Pancreatitis, Acute Pancreatitis, Endoscopy, and Colonoscopy. Dr. Kothari is currently accepting new patients.
University Medical Associates Of The Medical University Of South Carol
Badih Elmunzer is a Gastroenterologist in Charleston, South Carolina. Dr. Elmunzer is rated as an Elite provider by MediFind in the treatment of Hereditary Pancreatitis. His top areas of expertise are Hereditary Pancreatitis, Acute Pancreatitis, Choledocholithiasis, Endoscopy, and Stent Placement. Dr. Elmunzer is currently accepting new patients.
M Health Fairview Pediatric Specialty Clinic - Discovery
Sarah Jane Schwarzenberg, MD, is a pediatric gastroenterologist and hepatologist who cares for children with pancreatitis, cystic fibrosis and liver disease. She specializes in performing pediatric liver transplants and total pancreatectomy and islet auto-transplants. Dr. Schwarzenberg is rated as an Elite provider by MediFind in the treatment of Hereditary Pancreatitis. Her top areas of expertise are Childhood Pancreatitis, Chronic Pancreatitis, Hereditary Pancreatitis, Pancreatectomy, and Islet Cell Transplantation.
Summary: This is an observational prospective study to develop predictive biomarkers for pain response in participants with chronic pancreatitis scheduled for endoscopic therapy. Participants will undergo baseline assessments including electroencephalography (EEG), quantitative sensory testing (QST), and psychosocial questionnaires. Response to endoscopic therapy will be assessed at approximately 3, 6, 12 ...
Summary: This randomized trial will look at whether placing two cystic duct stents is more effective than one cystic duct stent in preventing recurrent gallbladder disease (cholecystitis, gallstone pancreatitis, or biliary colic) among patients who are not immediate surgical candidates for removal of their gallbladder. The study will evaluate the safety profile, including rates of recurrent cholecystitis, ...
Published Date: October 01, 2012
Published By: National Institutes of Health