Learn About Hereditary Pancreatitis
Hereditary pancreatitis is a genetic condition characterized by recurrent episodes of inflammation of the pancreas (pancreatitis). The pancreas produces enzymes that help digest food, and it also produces insulin, a hormone that controls levels of blood glucose, also called blood sugar. Episodes of pancreatitis can lead to permanent tissue damage and loss of pancreatic function.
Mutations in the PRSS1 gene cause most cases of hereditary pancreatitis. The PRSS1 gene provides instructions for making an enzyme called cationic trypsinogen. This enzyme is produced in the pancreas and helps with the digestion of food. When cationic trypsinogen is needed, it is released (secreted) from the pancreas and transported to the small intestine, where it is cut (cleaved) into its working or active form called trypsin. When digestion is complete and trypsin is no longer needed, the enzyme is broken down.
Hereditary pancreatitis is thought to be a rare condition. In Europe, its prevalence is estimated to be 3 to 6 per million individuals.
When hereditary pancreatitis is caused by mutations in the PRSS1 gene, it is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder. In some cases, an affected person inherits the PRSS1 gene mutation from one affected parent. Other cases result from new mutations in the gene and occur in people with no history of the disorder in their family.
University Medical Associates Of The Medical University Of South Carol
Badih Elmunzer is a Gastroenterologist in Charleston, South Carolina. Dr. Elmunzer is rated as an Elite provider by MediFind in the treatment of Hereditary Pancreatitis. His top areas of expertise are Hereditary Pancreatitis, Acute Pancreatitis, Choledocholithiasis, Endoscopy, and Stent Placement. Dr. Elmunzer is currently accepting new patients.
M Health Fairview Pediatric Specialty Clinic - Discovery
Sarah Jane Schwarzenberg, MD, is a pediatric gastroenterologist and hepatologist who cares for children with pancreatitis, cystic fibrosis and liver disease. She specializes in performing pediatric liver transplants and total pancreatectomy and islet auto-transplants. Dr. Schwarzenberg is rated as an Elite provider by MediFind in the treatment of Hereditary Pancreatitis. Her top areas of expertise are Childhood Pancreatitis, Chronic Pancreatitis, Hereditary Pancreatitis, Pancreatectomy, and Islet Cell Transplantation.
University Of Pittsburgh Physicians, Department Of Medicine, Division Of Gastroenterology
David Whitcomb, MD, PhD, specializes in gastroenterology and is board-certified in internal medicine by the American Board of Internal Medicine. He is affiliated with UPMC Presbyterian. Dr. Whitcomb completed his fellowship and residencies at the Duke University School of Medicine and medical degree at Ohio State University College of Medicine. Dr. Whitcomb is rated as an Elite provider by MediFind in the treatment of Hereditary Pancreatitis. His top areas of expertise are Hereditary Pancreatitis, Chronic Pancreatitis, Acute Pancreatitis, Pancreaticoduodenectomy, and Pancreatectomy.
Summary: The Coordinating and Data Management Center (CDMC) at MD Anderson Cancer will be responsible for the coordination and data management for the Evaluation of a mixed meal test for Diagnosis and characterization of Type 3c diabetes mellitus secondary to pancreatic cancer and chronic pancreatitis (DETECT), which is part of the NIH U01 funded Consortium for the Study of Chronic Pancreatitis, Diabetes, ...
Summary: The Coordinating and Data Management Center (CDMC) at MD Anderson Cancer will be responsible for the coordination and data management for the Prospective Evaluation of Chronic Pancreatitis for Epidemiologic and Translational Studies (PROCCEED) Study, which is part of the NIH U01 funded Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC). No patient enrollment ...
Published Date: October 01, 2012
Published By: National Institutes of Health