Antihypertensive and Vascular-Protective Effects of Wild Blueberries in Middle-Aged/Older Men and Postmenopausal Women.

Who is this study for? Older adult patients with Cardiovascular Disease
What treatments are being studied? Blueberry Powder
Status: Recruiting
Location: See location...
Intervention Type: Dietary supplement
Study Type: Interventional
Study Phase: Phase 1/Phase 2
SUMMARY

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. Aging is the primary risk factor for CVD, in large part due to adverse modifications to the arteries. These modifications include vascular endothelial dysfunction and arterial stiffness. Vascular endothelial dysfunction is an initiating step in atherosclerosis, and is primarily caused by reduced nitric oxide (NO) bioavailability secondary to excessive superoxide-driven oxidative stress and inflammation. Endothelial dysfunction leads to arterial stiffness and the development of hypertension (HTN) which further increases CVD. Greater than 2/3 of the US population has elevated blood pressure or stage 1-HTN. As such, interventions that improve vascular endothelial dysfunction by increasing NO bioavailability and mitigating excessive oxidative stress and inflammation are needed. Blueberries are rich in bioactive compounds including flavonoids, phenolic acids, and pterostilbene. These compounds and their metabolites have been shown to attenuate oxidative stress and inflammation. The primary goal of this study is to assess the efficacy of blueberries to improve reduce blood pressure and improve vascular endothelial dysfunction and arterial stiffness in middle-aged/older men with elevated blood pressure or stage 1-HTN.

Eligibility
Participation Requirements
Sex: Male
Minimum Age: 45
Maximum Age: 70
Healthy Volunteers: t
View:

• Men and postmenopausal women

• Aged 45-70 years

• Elevated blood pressure or stage 1-Hypertension

• Ability to provide informed consent

Locations
United States
Colorado
Food and Nutrition Clinical Research Laboratory
RECRUITING
Fort Collins
Contact Information
Primary
Sarah A Johnson, PhD, RDN
sarah.johnson@colostate.edu
970-491-3807
Time Frame
Start Date: 2020-01-01
Estimated Completion Date: 2025-12-31
Participants
Target number of participants: 58
Treatments
Experimental: Blueberry
22 g blueberry powder per day
Placebo_comparator: Control
22 g placebo control powder per day
Related Therapeutic Areas
Sponsors
Collaborators: Wild Blueberry Association of North America
Leads: Colorado State University

This content was sourced from clinicaltrials.gov