Preconception to pOst-partum Study of Cardiometabolic Health in Primigravid PregnancY

Status: Recruiting
Location: See all (7) locations...
Study Type: Observational
SUMMARY

Women who experience placental complications (syndromes) during pregnancy, such as pre-eclampsia (high blood pressure and kidney problems), gestational hypertension (high blood pressure during pregnancy) and fetal growth restriction (baby being small) have twice the risk of developing heart disease and diabetes later in life, compared to women who have a healthy pregnancy. This study aims to assess risk factors for heart disease and diabetes in women who are actively trying to conceive, before and during their pregnancy, and 9-12 months after delivery of their baby, to see whether placental syndromes make a difference to their heart health. This will allow us to understand, if, and how, placental syndromes increase the risk of heart disease and diabetes, and, therefore, how best to reduce this risk and potentially prevent placental syndromes in the future. The investigators will also recruit women who are NOT planning pregnancy, as a control group.

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Maximum Age: 45
Healthy Volunteers: t
View:

⁃ To be included in the trial the participant must:

• Nulliparous (no previous pregnancy beyond 20 weeks' gestation)

• Actively considering pregnancy within approximately 12 months

• Aged between 18 and 45 years

• Ability to consent and willing to participate

⁃ To be included in the trial the participant must:

• Nulliparous (no previous pregnancy beyond 20 weeks' gestation)

• Not planning to conceive during next 18 months

• Aged between 18 and 45 years

• Ability to consent and willing to participate

Locations
Other Locations
United Kingdom
Cambridge University Hospitals NHS Foundation Trust
RECRUITING
Cambridge
NHS Greater Glasgow and Clyde
RECRUITING
Glasgow
Imperial College Healthcare NHS Trust
RECRUITING
London
King's College Hospital NHS Foundation Trust
NOT_YET_RECRUITING
London
St George's University Hospitals NHS Foundation Trust
NOT_YET_RECRUITING
London
University College London Hospitals NHS Foundation Trust
NOT_YET_RECRUITING
London
Manchester University NHS Foundation Trust
NOT_YET_RECRUITING
Manchester
Contact Information
Primary
Heike Templin
cuh.poppycctu@nhs.net
0044 1223 250874
Time Frame
Start Date: 2023-05-24
Estimated Completion Date: 2052-12
Participants
Target number of participants: 3500
Treatments
Pregnancy ~3000 participants
Actively planning to conceive within approximately 12 months of study registration. No previous pregnancies.
Non-Pregnancy ~500 participants
Not planning to conceive within 18 months of study registration. No previous pregnancies.
Sponsors
Collaborators: University of Cambridge, Wellcome Trust, St George's, University of London, Imperial College London, University of Glasgow, University of Bristol, University College, London, King's College London
Leads: Cambridge University Hospitals NHS Foundation Trust

This content was sourced from clinicaltrials.gov