Learn About Preeclampsia

What is the definition of Preeclampsia?

Preeclampsia is high blood pressure and signs of liver or kidney damage that occur in women after the 20th week of pregnancy. While rare, preeclampsia also may occur in a woman after delivering her baby, most often within 48 hours. This is called postpartum preeclampsia.

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What are the alternative names for Preeclampsia?

Toxemia; Pregnancy-induced hypertension (PIH); Gestational hypertension; High blood pressure - preeclampsia

What are the causes of Preeclampsia?

The exact cause of preeclampsia is unknown. It occurs in about 3% to 7% of all pregnancies. The condition is thought to start in the placenta. Factors that may lead to preeclampsia developing include:

  • Autoimmune disorders
  • Blood vessel problems
  • Your diet
  • Your genes

Risk factors for the condition include:

  • First pregnancy
  • Past history of preeclampsia
  • Multiple pregnancy (twins or more)
  • Family history of preeclampsia
  • Obesity
  • Being older than age 35
  • Being African American
  • History of diabetes, high blood pressure, or kidney disease
  • History of thyroid disease
What are the symptoms of Preeclampsia?

Often, women who have preeclampsia do not feel sick.

Symptoms of preeclampsia can include:

  • Swelling of the hands and face or eyes (edema)
  • Sudden weight gain over 1 to 2 days or more than 2 pounds (0.9 kg) a week

Note: Some swelling of the feet and ankles is considered normal during pregnancy.

Symptoms of severe preeclampsia include:

  • Headache that does not go away or becomes worse.
  • Trouble breathing.
  • Belly pain on the right side, below the ribs. Pain may also be felt in the right shoulder, and can be confused with heartburn, gallbladder pain, a stomach virus, or kicking by the baby.
  • Not urinating very often.
  • Nausea and vomiting (a worrisome sign).
  • Vision changes, including temporary blindness, seeing flashing lights or spots, sensitivity to light, and blurry vision.
  • Feeling lightheaded or faint.
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What are the current treatments for Preeclampsia?

Preeclampsia often resolves after the baby is born and the placenta is delivered. However, it may persist or even begin after delivery.

Most often, at 37 weeks, your baby is developed enough to be healthy outside of the womb.

As a result, your provider will likely want your baby to be delivered so the preeclampsia does not get worse. You may get medicines to help trigger labor, or you may need a C-section.

If your baby is not fully developed and you have mild preeclampsia, the disease can often be managed at home until your baby has matured. The provider will recommend:

  • Frequent doctor visits to make sure you and your baby are doing well.
  • Medicines to lower your blood pressure (sometimes).
  • The severity of preeclampsia may change quickly, so you'll need very careful follow-up.

Complete bed rest is no longer recommended.

Sometimes, a pregnant woman with preeclampsia is admitted to the hospital. This allows the health care team to watch the baby and mother more closely.

Treatment in the hospital may include:

  • Close monitoring of the mother and baby
  • Medicines to control blood pressure and prevent seizures and other complications
  • Steroid injections for pregnancies under 34 weeks gestation to help speed up the development of the baby's lungs

You and your provider will continue to discuss the safest time to deliver your baby, considering:

  • How close you are to your due date.
  • The severity of the preeclampsia. Preeclampsia has many severe complications that can harm the mother.
  • How well the baby is doing in the womb.

The baby must be delivered if there are signs of severe preeclampsia. These include:

  • Tests that show your baby is not growing well or is not getting enough blood and oxygen.
  • The bottom number of your blood pressure is over 110 mm Hg or is greater than 100 mm Hg consistently over a 24-hour period.
  • Abnormal liver function test results.
  • Severe headaches.
  • Pain in the belly area (abdomen).
  • Seizures or changes in mental function (eclampsia).
  • Fluid buildup in the mother's lungs.
  • HELLP syndrome (rare).
  • Low platelet count or bleeding.
  • Low urine output, a lot of protein in the urine, and other signs that your kidneys are not working properly.
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What is the outlook (prognosis) for Preeclampsia?

Sign and symptoms of preeclampsia most often go away within 6 weeks after delivery. However, the high blood pressure sometimes gets worse the first few days after delivery. You are still at risk for preeclampsia for up to 6 weeks after delivery. This postpartum preeclampsia carries a higher risk of death. If you notice any symptoms of preeclampsia, contact your health care provider right away.

If you have had preeclampsia, you are more likely to develop it again during another pregnancy. In most cases, it is not as severe as the first time.

If you have high blood pressure during more than one pregnancy, you are more likely to have high blood pressure when you get older.

What are the possible complications of Preeclampsia?

Rare but severe immediate complications for the mother can include:

  • Bleeding problems
  • Seizure (eclampsia)
  • Fetal growth retardation
  • Premature separation of the placenta from the uterus before the baby is born
  • Rupture of the liver
  • Stroke
  • Death (rarely)

Having a history of preeclampsia makes a woman a higher risk for future problems such as:

  • Heart disease
  • Diabetes
  • Kidney disease
  • Chronic high blood pressure
When should I contact a medical professional for Preeclampsia?

Call your provider if you have symptoms of preeclampsia during your pregnancy or after delivery.

How do I prevent Preeclampsia?

There is no sure way to prevent preeclampsia.

  • If your doctor thinks you are at high risk of developing preeclampsia, they may suggest that you start baby aspirin (81 mg) daily late in the first trimester or early in the second trimester of your pregnancy. However, DO NOT start baby aspirin unless you have consulted with your doctor first.
  • If your doctor thinks your calcium intake is low, they may suggest that you take a calcium supplement daily.
  • There are no other specific preventive measures for preeclampsia.

It is important for all pregnant women to start prenatal care early and continue it through the pregnancy and after delivery.

What are the latest Preeclampsia Clinical Trials?
Analysis of Maternal Plasma/Urine/Hair Magnesium and Vanadium Levels in Preeclampsia (PrE)

Introduction: Vanadium important pollutants produced from anthropogenic activities, has been suggested to be embryotoxic and fetotoxic in a lot of studies. Magnesium sulfate therapy is used very common to prevent seizures in women with preeclampsia. However, the causes of preeclampsia are little known and heavy metals merit further investigation. The investigators will be tested whether late - onset preeclampsi...

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Labetalol or Nifedipine for Control of Postpartum Hypertension: A Randomized Controlled Trial

Summary: Randomized trial comparing risk of hospital readmission and hypertensive complications between patients managed on Labetalol compared to Nifedipine.

What are the Latest Advances for Preeclampsia?
Sildenafil during the 2nd and 3rd Trimester of Pregnancy: Trials and Tribulations.
The impact of levothyroxine therapy on the pregnancy, neonatal and childhood outcomes of subclinical hypothyroidism during pregnancy: An updated systematic review, meta-analysis and trial sequential analysis.
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Effect of Compound Danshen Injection Combined with Magnesium Sulfate on Oxidative Stress, TNF-α, NO, and Therapeutic Efficacy in Severe Preeclampsia.
Who are the sources who wrote this article ?

Published Date: June 08, 2020
Published By: LaQuita Martinez, MD, Department of Obstetrics and Gynecology, Emory Johns Creek Hospital, Alpharetta, GA. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

What are the references for this article ?

American College of Obstetricians and Gynecologists; Task Force on Hypertension in Pregnancy. Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists' Task Force on Hypertension in Pregnancy. Obstet Gynecol. 2013;122(5):1122-1131. PMID: 24150027 pubmed.ncbi.nlm.nih.gov/24150027/.

Harper LM, Tita A, Karumanchi SA. Pregnancy-related hypertension. In: Resnik R, Lockwood CJ, Moore TR, Greene MF, Copel JA, Silver RM, eds. Creasy and Resnik's Maternal-Fetal Medicine: Principles and Practice. 8th ed. Philadelphia, PA: Elsevier; 2019:chap 48.

Sibai BM. Preeclampsia and hypertensive disorders. Landon MB, Galan HL, Jauniaux ERM, et al, eds. Gabbe's Obstetrics: Normal and Problem Pregnancies. 7th ed. Philadelphia, PA: Elsevier; 2021:chap 38.