The Efficacy of Phosphodiesterase Inhibitors in Patients With Group 2 Pulmonary Hypertension

Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of this clinical trial is to test the efficacy of tadalafil in patients with group II pulmonary hypertension with elevated pulmonary vascular resistance (PVR). The main question it aims to answer is: • Can tadalafil improve patients with group II pulmonary hypertension with elevated PVR? Participants will undergo right heart catheterization (RHC) to make sure they are fulfilling the inclusion criteria, then will be asked to take tadalafil 20 mg for two weeks then 40 mg if tolerated for 12 weeks, then participants will be followed up. Investigators will compare the drug group with another age- and sex- matched control placebo group.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 75
Healthy Volunteers: f
View:

• group 2 pulmonary hypertension with precapillary component with PVR more than 4 by RHC

• Patients should be on HF medical therapy 90 days before enrollment in the study.

Locations
Other Locations
Egypt
Beni Suef University
RECRUITING
Cairo
Contact Information
Primary
Marina Awad Zaher, Master
Marinaawad984@gmail.com
201271159549
Time Frame
Start Date: 2023-01-10
Estimated Completion Date: 2026-02
Participants
Target number of participants: 48
Treatments
Active_comparator: tadalafil-receiving arm
Patients will take tadalafil for the 12 week period of follow up, in addition to the standard evidence-based therapy for the left heart disease.
No_intervention: Tadalafil non-receiving arm
Patients will not take tadalafil for the 12 weeks follow up, only standard evidence-based therapy for the left heart disease.
Related Therapeutic Areas
Sponsors
Leads: Beni-Suef University

This content was sourced from clinicaltrials.gov