The Use of Propranolol in the Perioperative Period of Resectable Gastrointestinal Tumors and the Study of Its Immune Mechanism Research
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 2
SUMMARY
In this study, perioperative propranolol β-blockade was administered to patients with surgically resectable primary gastrointestinal tumors to explore the safety, efficacy, and alleviation of perioperative psychological stress. At the same time, a multi-omics study was conducted using clinical samples to explore the activation of anti-tumor immune response and its mechanism.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 65
Healthy Volunteers: f
View:
• Surgically resectable primary gastric cancer and colorectal cancer;
• Age greater than 18 years old and less than 65 years old;
• Negative pregnancy test for women of childbearing age;
• ECOG score ≤2;
• Signed informed consent.
• Resting blood pressure greater than 100/60mmHg, heart rate greater than 60 beats per minute.
Locations
Other Locations
China
Huashan Hospital, Fudan University
RECRUITING
Shanghai
Time Frame
Start Date: 2024-12-01
Estimated Completion Date: 2027-04-30
Participants
Target number of participants: 40
Treatments
Experimental: propranolol (beta-blocker used treat high blood pressure)+surgeries
Related Therapeutic Areas
Sponsors
Leads: Huashan Hospital