Non-Invasive HaemoDYNAMICs in Primary and Secondary Hypertension: the DYNAMIC-study
Status: Recruiting
Location: See all (2) locations...
Intervention Type: Dietary supplement, Drug
Study Type: Observational
SUMMARY
The primary aim of the present study was to examine the haemodynamic changes in primary hypertension and secondary hypertension (renal diseases, endocrine diseases, obesity-associated hypertension) with a non-invasive haemodynamic measurement protocol utilizing radial pulse wave analysis and whole-body impedance cardiography in both supine position and during head-up tilt. For comparison, haemodynamics of subjects with chronic fatigue syndrome will also be recorded.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 99
Healthy Volunteers: t
View:
• Independent, community-dwelling adults
• Hypertensive subjects (primary or secondary hypertension)
• Normotensive control subjects
• Subjects with aortic stenosis (subgroup aortic stenosis)
• Participants of Ironman Triathlon competition
Locations
Other Locations
Finland
Tampere University
RECRUITING
Tampere
Tampere University Hospital
RECRUITING
Tampere
Time Frame
Start Date: 2006-05-25
Estimated Completion Date: 2025-12-31
Participants
Target number of participants: 2000
Treatments
DYNAMIC (ongoing)
Subjects with primary or secondary hypertension and normotensive control subjects. In addition haemodynamic recordings to 50 subjects suffering from chronic fatigue syndrome will be performed.
AERO-DYNAMIC (recordings completed)
Subjects who had voluntarily decided to participate in a professionally coached marathon school (Varala Sports Institute, Tampere) were given the chance for haemodynamic recordings before, during and after the training protocol.
Liquorice (recordings completed)
Normotensive subjects, daily liquorice ingestion (daily glycyrrhizin dose 290-370 mg) for 2 weeks, haemodynamic measurements before and after the intervention.
Milk polypeptides (recordings completed)
Daily ingestion of yoghurt containing small milk casein-derived polypeptides for 12 weeks versus placebo yoghurt.
Bisoprolol (recordings completed)
Hypertensive subjects, bisoprolol 5 mg once daily versus placebo in a double-blind, cross-over protocol.
Aortic stenosis (ongoing)
Subjects with aortic stenosis confirmed by echocardiography
Methodological (recordings completed)
35 normotensive subjects who received research drugs (nitroglycerin, salbutamol, placebo resoriblet, placebo inhalation, L-arginine infusion, saline infusion) in a placebo-controlled, double-blinded manner
Participants of Ironman Triathlon
Altogether 80 athletes participating in a full length Ironman competition. Non-invasive recordingds are performed under normal conditions during the training period and after completion of a full-length Ironman competition.
Authors
Related Therapeutic Areas
Sponsors
Collaborators: Tampere Tuberculosis Foundation, Finnish Kidney Foundation, Paavo Nurmi Foundation, Medical Research Fund of the Tampere University Hospital, Finland, Finnish Medical Foundation, Päivikki and Sakari Sohlberg Foundation, Finland, Finnish Foundation for Cardiovascular Research, Aarne Koskelo Foundation, Finnish Cultural Foundation, Sigrid Jusélius Foundation
Leads: Tampere University