Dose-Response Effects of Inspiratory Muscle Strength Training on Blood Pressure and Vascular Function

Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This study will assess the dose-response effects of Inspiratory Muscle Strength Training (IMST) in adults with above-normal systolic blood pressure over a 6-week period.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Age ≥18 years

• Resting SBP ≥120 mmHg as measured during screening 1 \& 2

• Free from serious CV or metabolic diseases as identified by self-report and blood chemistry analysis.

• No contraindications to IMST (recent abdominal surgery, ruptured eardrum, asthma with very low symptom perception, fractured ribs, or pneumothorax)

• Language: English-speaking, with ability to comprehend study materials and instructions.

• Pre-visit Compliance: Willing to comply with pre-visit instructions (avoiding food and caffeine ≥ 3 hours, vigorous exercise, alcohol, and non-prescribed medications ≥ 24 hours) prior to each measurement visit.

• Lifestyle: Non-smokers (defined as self-report of not smoking cigarettes or vaping over the past year).

Locations
United States
Minnesota
University of Minnesota
RECRUITING
Minneapolis
Contact Information
Primary
Hannah Westerberg
lewi1241@umn.edu
612-624-1588
Time Frame
Start Date: 2025-10-24
Estimated Completion Date: 2027-03-31
Participants
Target number of participants: 144
Treatments
Active_comparator: 15 Breaths/ Day
All sessions will be performed at 75% of each participant's PI max 7 days per week, for 6 weeks, using the POWERbreathe K5 device. Each session will take approximately 3-10 minutes depending on the assigned dose group.
Active_comparator: 30 Breaths/ Day
All sessions will be performed at 75% of each participant's PI max 7 days per week, for 6 weeks, using the POWERbreathe K5 device. Each session will take approximately 3-10 minutes depending on the assigned dose group.
Active_comparator: 45 Breaths/ Day
All sessions will be performed at 75% of each participant's PI max 7 days per week, for 6 weeks, using the POWERbreathe K5 device. Each session will take approximately 3-10 minutes depending on the assigned dose group.
Related Therapeutic Areas
Sponsors
Leads: University of Minnesota

This content was sourced from clinicaltrials.gov

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