Prescription of Step Counts for Targeted Changes in Body Composition and Cardiometabolic Risk in Overweight/Obese Adults

Status: Recruiting
Location: See location...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The prevalence of overweight and obesity remains epidemic in the United States, with some of the highest rates seen in older adults. While this phenomenon is certainly multifactorial, a good deal of evidence suggests that insufficient physical activity (PA) contributes significantly. Pilot data recently collected in a laboratory indicates a strong, inverse relationship between daily step counts and body fatness and cardiometabolic risk (CMR) factors when step counts are expressed relative to fat mass in young adults. This expression of PA may be especially predictive of body composition because it is influenced by factors that influence appetite and energy intake, energy expenditure, and the energy reservoir that is represented by body fat stores, all three elements of the settling point model of body weight. The strength of this relationship suggests that prescription of step counts that consider current body weight and composition, and weight loss goal, may yield predictable changes in weight and CMR in adults eating ad libitum. The long-term objective of this study is to quantify the relationship between daily step counts and body composition in young, middle aged, and older adults who are overweight/obese and develop a regression model that can be used to prescribe physical activity (daily step counts) for achieving a specific target body weight and predictably improving CMR risk for young, middle-aged, and older adult men and women over eight months while eating ad libitum. To achieve this objective, investigators will undertake two specific aims: 1) quantify the relationship between average steps·kg fat mass-1·day-1 and body composition/CMR profiles in healthy, overweight, and obese adults 20-39 years, 40-59 years, 60-79 years, and 80-plus years old, using inexpensive, widely available triaxial pedometers while eating ad libitum, and 2) quantify the efficacy of employing targeted step counts expressed as steps·kg fat mass-1·day-1 using the model developed in Aim 1 for producing predictable improvements in body composition and CMR factors in overweight and obese adults 20-39, 40-59, 60-79, and 80-plus years old, over 8 months while eating ad libitum. This study will result in a regression model that may significantly improve the way that PA is prescribed for weight management, with vast clinical and public health implications.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 20
Healthy Volunteers: t
View:

• ages of 20 years and older

• otherwise healthy adults on prescription medication to treat hypertension or osteoarthritic conditions are eligible to participate

• sedentary people, or people who report engaging in regular walking (no regular structured exercise for at least the past six months)

• relatively stable weight over the previous 6 months (less than 5% fluctuation in body weight)

Locations
United States
Georgia
Kennesaw State Universityh
RECRUITING
Kennesaw
Contact Information
Primary
Robert Buresh, PhD
rburesh@kennesaw.edu
470-578-6488
Backup
Brian Kliszczewicz, PhD
bkliszcz@kennesaw.edu
Time Frame
Start Date: 2025-01-13
Estimated Completion Date: 2027-08-31
Participants
Target number of participants: 200
Treatments
Experimental: Regular accumulation of step count targets to achieve predictable weight loss
Participants will be provided a step count goal that may be expected to result in a weight loss of 5% of body weight, and will carry a pedometer for 8 months while striving to consistently reach the step count target.
Related Therapeutic Areas
Sponsors
Leads: Kennesaw State University

This content was sourced from clinicaltrials.gov