Typing of Gut Microbiota in Patients With Limb Lymphedema and Recurrent Lymphangitis, a Prospective Observational Study
Lymphedema is a chronic and progressive disease of the lymphatic vessels which affects about 300 million people worldwide. Patients may experience recurrent soft tissue infection of the limb affected by lymphedema, in terms of erysipelas, lymphangitis or cellulitis. No previous study has ever investigated the possible role of the gut microbiota in the genesis of acute infectious/inflammatory episodes in these patients. Our hypothesis is that lymphedema patients with recurrent soft tissue infections are characterized by pro-inflammatory changes in the microbiota.
• 18-85 years
• primary or secondary, upper or lower limb lymphedema, I-II-III stage ISL
• at least 3 episodes of soft tissue infection in an year, in the last 2 years
• consent to participate in the study
• 18-85 years
• primary or secondary, upper or lower limb lymphedema, stage I-II-III (ISL)
• no episodes of soft tissue infection in the last 2 years
• consent to participate in the study