Prospective Observational Cohort Survey to Assess the Prevalence and Development of Sarcopenia and the Correlation of Muscle Mass and Outcome in Patients with Cirrhosis by Skeletal Muscle Ultrasound.
Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Observational
SUMMARY
The goal of this observational cohort study is to learn about loss of muscle mass and muscle strength (sarcopenia) in patients with cirrhosis. The main question\[s\] it aims to answer are: * what is the prevalence and development of sarcopenia in cirrhosis? * what is the role of malnutrition? Participants will * undergo a muscle ultrasound of the lower and upper limb muscles * handgrip strength will be measured * malnutrition screening and assessment * complete a questionnaire to assess quality of life
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• diagnosis of cirrhosis and follow-up in the University Hospital of Antwerp
Locations
Other Locations
Belgium
University Hospital Antwerp
RECRUITING
Edegem
Contact Information
Primary
Karolien Dams, MD
karolien.dams@uza.be
+3238213635
Backup
Stany Perkisas, MD, PhD
stany.perkisas@zna.be
Time Frame
Start Date: 2024-05-06
Estimated Completion Date: 2027-09-30
Participants
Target number of participants: 60
Treatments
Child A
The impact of sarcopenia in patients with cirrhosis may also be influenced by sex, severity of hepatic dysfunction, and etiology of cirrhosis. For this reason we aim for an homogeneous population, with a balanced distribution over the Child Pugh classification with a homogeneous population of at least 50%.~Child A patients still have a good hepatic function.
Child B
Child B patients have a moderately impaired hepatic function.
Child C
Patients with Child C have an advanced hepatic dysfunction, within this group we will also look at patients with acute on chronic liver failure.(ACLF)
Related Therapeutic Areas
Sponsors
Leads: University Hospital, Antwerp