Research on the Treatment of Severe Community-acquired Pneumonia in Children

Status: Recruiting
Location: See all (3) locations...
Intervention Type: Drug, Other
Study Type: Interventional
Study Phase: Phase 4
SUMMARY

The need for glucocorticoid therapy in children with severe community-acquired pneumonia in the acute phase of the disease remains unclear. The implementation of this study could provide strong evidence on the need for adjuvant glucose therapy in children with severe community-acquired pneumonia.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 1 month
Maximum Age: 18
Healthy Volunteers: f
View:

• 1 month-\< 18 years old.

• Clinical diagnosis of community-acquired pneumonia (fever, cough, sputum, chest pain, dyspnea, abnormal breath sounds in the lungs, imaging pneumonia changes).

• Meet any of the following:

‣ (1) the general condition is very poor;

⁃ (2) refusal to eat or dehydration;

⁃ (3) Significantly increased respiratory rate (70 times/min \> infants, 50 times/min for older children\>);

⁃ (4) dyspnea (three concave sign, moaning, nasal flapping)

⁃ (5) hypoxemia (cyanosis, transcutaneous oxygen saturation\< 92% (not oxygenated));

⁃ (6) Pulmonary infiltration≥ 2/3 lung or multilobar infiltration;

⁃ (7) There is a pleural effusion;

⁃ (8) Extrapulmonary complications

Locations
Other Locations
China
Baoding Children's Hospital
RECRUITING
Baoding
Beijing Children's Hospital
RECRUITING
Beijing
Beijing Fangshan District Health Care Hospital
RECRUITING
Beijing
Contact Information
Primary
Baoping Xu
xubaopingbch@163.com
13370115002
Time Frame
Start Date: 2023-03-10
Estimated Completion Date: 2025-12-01
Participants
Target number of participants: 160
Treatments
Experimental: Experimental group
Prednisolone, oral, 2 mg/kg.d (maximum dose 60 mg/day), two or three times a day , 5 days.
Placebo_comparator: Placebo group
The same amount of placebo was taken orally as the trial for 5 days
Related Therapeutic Areas
Sponsors
Leads: Baoping XU

This content was sourced from clinicaltrials.gov