Efficacy of High-Intensity Transcranial Alternating Current Stimulation (Hi-tACS) in Treating Negative Symptoms of Schizophrenia
The goal of this clinical trial is to investigate whether Hi-tACS is effective and safe in treating negative symptoms of schizophrenia. Schizophrenic patients will receive treatment (Hi-tACS or shame stimulation) for 2 weeks. Negative symptoms, cognitive functioning, social functioning, and quality of life of intervention group and control group were assessed and compared between the two groups at baseline, 2 weeks, and 3 months post-intervention.
• Han Chinese population;
• Age ≥ 18 years;
• Education level ≥ 6 years, able to fill out questionnaires on their own, and having sufficient audiovisual level to complete the necessary examinations;
• Meets DSM-5 diagnostic criteria for schizophrenia as assessed by MINI 7.0;
• Residual negative symptoms, with at least one item ≥2 on the negative subscale of PANSS (N1-N7);
• Taking second-generation atypical antipsychotic medication, with no medication or dosage adjustments in the last two weeks
• Patients and guardians agreed to participate in the study and signed an informed consent form.