Monocentric Randomized Experimental Pilot Trial Investigating the Influence of Intermittent Fasting According to the 16:8 Method With and Without Medium-chain Triglycerides (MCTs) on Seizure Frequency, Biomarkers and Neural Networks in Patients With Drug-resistant Epilepsy
Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
The objective of the prospective monocentric pilot trial is to investigate the influence of intermittent fasting with or without a once-daily intake with medium chain triglycerides (MCTs) on the frequency of seizures in patients with therapy-refractory epilepsy. The effects of 12 weeks intermittent fasting according to the 16:8 method (IF 16:8) are compared to 12 weeks intermittent fasting with additional intake of exogenous MCTs (IF MCT 16:8) in a within-subject-crossover-design in 28 patients with drug-resistant epilepsy.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Subjects able to provide informed consent
• Drug-resistant epilepsy
• At least 3 seizures per month
Locations
Other Locations
Germany
Philipps University Marburg, Faculty of Medicine, Department of Neurology, Epilepsy Center
RECRUITING
Marburg
Contact Information
Primary
Wiebke Hahn, MD
Hahnwi@staff.uni-marburg.de
+49 642158 65348
Time Frame
Start Date: 2023-07-25
Estimated Completion Date: 2025-12-31
Participants
Target number of participants: 28
Treatments
Active_comparator: IF 16:8
12 weeks intermittent fasting according to the 16:8 method (IF 16:8)
Experimental: IF MCT 16:8
12 weeks intermittent fasting with additional intake of exogenous MCTs (IF MCT 16:8)
Sponsors
Leads: University Hospital Marburg